TACE联合热消融与单独TACE治疗结直肠癌肝转移疗效:Meta分析

Efficacy of TACE combined with thermal ablation and TACE alone for treatment of colorectal liver metastasis:Meta-analysis

目的系统评价TACE联合热消融与单独TACE治疗结直肠癌肝转移(CRLM)的疗效。方法检索Embase、Cochrane Library、PubMed、中国知网、维普数据库和万方医学网中自建库至2021年11月25日关于TACE联合热消融与单独TACE治疗CRLM的文献,依据纳入及排除标准进行筛选;以RevMan 5.3软件和Stata 15.1软件分析TACE联合热消融与单独TACE治疗CRLM的疗效。结果共纳入15篇文献、1570例CRLM患者。TACE联合热消融治疗有效率[OR=4.39,95%CI(3.16,6.12)]、疾病控制率[OR=3.30,95%CI(2.22,4.92)]及术后1年[OR=3.00,95%CI(2.12,4.25)]、2年[OR=3.95,95%CI(2.94,5.29)]、3年生存率[OR=7.05,95%CI(4.73,10.50)]均高于单独TACE(P均<0.05)。结论TACE联合热消融治疗CRLM优于单独TACE。

Objective To systematically evaluate the efficacy of TACE combined with thermal ablation and TACE alone for treatment of colorectal liver metastasis(CRLM).Methods Published literature of TACE combined with thermal ablation and TACE alone for treatment of CRLM were searched before Nov 25,2021 in Embase,Cochrane Library,PubMed,CNKI,VIP and Wanfang Med Online databases and screened according to inclusion and exclusion criteria.RevMan 5.3 and Stata 15.1 software were used to analyze the efficacy of TACE combined with thermal ablation and TACE alone for treatment of CRLM.Results Totally 15 articles were enrolled,including 1570 CRLM patients.The effective rate(OR=4.39,95%CI[3.16,6.12],P<0.05),disease control rate(OR=3.30,95%CI[2.22,4.92],P<0.05),as well as 1-year(OR=3.00,95%CI[2.12,4.25],P<0.05),2-year(OR=3.95,95%CI[2.94,5.29],P<0.05)and 3-year survival rate(OR=7.05,95%CI[4.73,10.50],P<0.05)for TACE combined with thermal ablation were all higher than those for TACE alone(all P<0.05).Conclusion The efficacy of TACE combined with thermal ablation for treatment of CRLM was better than TACE alone.