基于金属铱(Ⅲ)配合物荧光探针的应用及研究进展

Application and research progress of fluorescent probes based on Iridium(Ⅲ)complexes

典型的过渡金属铱配合物主要是由金属铱为核心和三个双齿配体或者两个三齿配体形成具有六配位的畸变八面体构型的配合物,且铱配合物的发光大多是基于三线态的发光,发光性能与常见的有机荧光团相比有更长发光寿命,更大的斯托克位移。此外,光物理与光化学性质受配体所支配,可通过改变配体调控铱配合物的发光性能。因此它们得到了人们的关注,被广泛用于生物、医药、材料领域。本文简要介绍了金属铱(Ⅲ)配合物作为荧光探针在光动力治疗,生物活性小分子化合物、阴阳离子识别等方面的研究及应用。

A typical transition metal iridium complex is mainly composed of an iridium metal core and three double-coordinated ligands to form a complex with a six-coordinated distortion octahedral configuration.Because iridium complex probes are mostly based on triplet state,their luminescence performance has the advantages of longer luminescence lifetime and larger Stokes displacement compared with common organic fluorophores.In addition,photophysical and photochemical properties are governed by ligands,so it has attracted people’s attention and is widely used in the fields of biology and medical materials.This article briefly introduces the research and application of metal iridium(Ⅲ)complex fluorescent probes in photodynamic therapy,biologically active small molecule compounds,and anion and cation recognition.