陪同转介治疗模式在男性同性性行为人群艾滋病快速抗病毒治疗中的应用

Effectiveness of rapid initiation of antiretroviral therapy among HIV/AIDS patients of MSM with escorted services by community-based organizations

目的分析青岛市社会组织(CBO)陪同转介治疗模式在男性同性性行为(MSM)人群艾滋病(AIDS)快速抗病毒治疗(ART)中的效果,为后续相关工作和政策制定提供参考。方法采用回顾性研究方法,收集2019年青岛市某CBO陪同转介治疗服务的经MSM传播的HIV感染者和AIDS患者的基线和抗病毒治疗后的相关资料,分析评估ART效果。结果共纳入150例。接受CBO陪同转介治疗服务的HIV感染者/AIDS患者用药天数3(1,6)d,基线、治疗6个月、12个月CD4+T淋巴细胞计数分别为412.3(376.0~450.0)、603.8(549.6~666.9)、613.2(558.6~666.9)个/μl,三个时间比较差异有统计学意义(P<0.01)。与其他开展ART机构相比,CBO陪同转介治疗服务的患者7 d内服药率显著提高、服药天数显著降低,抗病毒治疗率、治疗6、12个月CD4+T淋巴细胞检测率和病毒载量检测率显著增加,差异均有统计学意义(P<0.01)。结论CBO陪同转介治疗模式有利于缩短ART开始时间,显著提高HIV感染者/AIDS患者的治疗率、服药依从性以及随访质量。

Objective To analyze the role of Qingdao community-based organizations(CBO)accompanying treatment model in the rapid initiation of antiretroviral therapy(ART)for HIV/AIDS patients of men who had sex with men(MSM),providing reference for subsequent related work and policy formulation.Methods A retrospective analysis was conducted to evaluate ART effects based on the collected baseline and post-antiviral treatment data of HIV infected persons and AIDS patients(HIV/AIDS patients)receiving escorted services by CBO in Qingdao in 2019.ART effect was evaluated.Results A total of 150 cases was enrolled.The average administration days were 3(1,6)days.The CD4+T lymphocyte counts were 412.3(376.0-450.0),603.8(549.6-666.9)and 613.2(558.6-666.9)/μl,respectively at baseline and after 6 and 12 months of treatment.There were significant differences in them among the three time points(P<0.01).Compared with other ART methods,the rate of 7-day oral administration was significantly increased,the number of days medication was significantly reduced and the rate of antiviral treatment,detection of CD4+T lymphocyte and detection rate of virus load were significantly increased at 6 and 12 months of treatment for the patients with escorted services by CBO(P<0.01).Conclusion The escorted services by CBO is helpful to shorten the start time of ART and improve the therapeutic qualities,medication maintenance and quality of life of MSM-HIV infected/AIDS patients.