二期梅毒口腔临床表现及血清学检测结果分析

Analysis of oral clinical manifestations and serological test results of secondary syphilis

目的分析二期梅毒患者血清学检测结果与其口腔临床表现的相关性,为临床诊疗提供参考依据。方法选取2016年1月至2020年12月于南京大学医学院附属口腔医院·南京市口腔医院就诊的二期梅毒患者30例进行回顾性分析,研究患者口腔临床表现(包括病损数目和临床病损分级)与血清学检测结果[快速血浆反应素环状卡片试验(rapid plasma reactin ring card test,RPR)滴度]的相关性。结果纳入研究的30例患者中,男14例,女16例;青年组(≤44岁)11例,中年组(45~59岁)10例,老年组(≥60岁)9例;各年龄组患者的性别分布差异无统计学意义(P>0.05)。患者的口腔黏膜病损表现为黏膜斑、黏膜炎,好发部位依次为唇、舌、咽、腭和颊部。与低RPR滴度组(<1∶128)相比,高RPR滴度组(≥1∶128)患者口腔黏膜病损数目较多、临床病损分级较高,差异均有统计学意义(均P<0.05)。结论伴有口腔黏膜病损的二期梅毒患者RPR滴度与口腔黏膜病损数目及临床病损分级密切相关。

Objective To analyze the correlation between serological test results and oral clinical manifestations of patients with secondary syphilis,and to provide reference for clinical diagnosis and treatment.Methods From January2016 to December 2020,30 patients with secondary syphilis were treated in Nanjing Stomatological Hospital and Nanjing Stomatological Hospital,School of Medicine,Nanjing University,and they were retrospectively analyzed to investigate the correlation between oral clinical manifestations(including the number and grade of lesions)and serological test results[rapid plasma reactin ring card test(RPR)titers].Results Among the 30 patients included in the study,14were male and 16 were female.There were 11 young people(≤44 years old),10 middle-aged people(45-59 years old)and 9 elderly people(≥60 years old).There was no significant difference in gender distribution among different age groups(P>0.05).The oral mucosal lesions of the patients were characterized by mucosal plaques and mucositis,and the most frequent sites were lips,tongue,pharynx,palate and buccal division.Patients with high RPR titer(≥1∶128)had more oral mucosal lesions and higher clinical lesion grade compared with patients with low RPR titer(<1∶128),with statistical significance(P<0.05).Conclusion RPR titer of secondary syphilis patients with oral mucosal lesions is closely related to the number of oral mucosal lesions and clinical lesions grade.