中性粒细胞与淋巴细胞比值联合血清CEA、CA199和CA724检测在早期胃癌筛查中的应用

Application of Neutrophil-to-Lymphocyte Ratio Combined with Serum CEA,CA199 and CA724 Detection in Early Gastric Cancer Screening

目的探讨中性粒细胞与淋巴细胞比值(NLR)联合血清CEA、CA199和CA724检测在早期胃癌筛查中的应用价值。方法收集100例早期胃癌患者(早期胃癌组)、100例胃良性病变者(良性组)和100例健康体检者(健康组)的临床资料。比较3组NLR、血清CEA、CA199和CA724水平,并通过受试者工作特征(ROC)曲线分析单独及联合指标检测的准确性、敏感度及特异度。结果早期胃癌组的NLR、血清CEA、CA199和CA724水平高于良性组和健康组(均P<0.05);良性组NLR和CA724水平高于健康组(均P<0.05)。联合检测区分早期胃癌患者和健康体检者的准确性为90.2%,敏感度为89%,特异度为83%;联合检测区分早期胃癌和胃良性病变的准确性为84.3%,敏感度为78%,特异度为86%。结论NLR和CA724水平与胃的病变程度有关;NLR联合血清CEA、CA199和CA724检测能提高早期胃癌筛查的准确性、敏感度和特异度,可为临床筛查提供参照。

Objective To investigate the value of neutrophil-to-lymphocyte ratio(NLR)combined with serum CEA,CA199 and CA724 detection in early gastric cancer screening.Methods The clinical data of 100 patients with early gastric cancer(early gastric cancer group),100 patients with benign lesions(benign group)and 100 healthy subjects(healthy group)were collected.The NLR and serum CEA,CA199 and CA724 levels were compared among the three groups.The accuracy,sensitivity and specificity of individual and combined indicators were detected by ROC curve analysis.Results The NLR and serum CEA,CA199 and CA724 levels in early gastric cancer group were higher than those in benign and healthy groups(all P<0.05).The NLR and CA724 level in benign group were higher than those in healthy group(all P<0.05).The accuracy,sensitivity and specificity of combined detection were respectively 90.2%,89% and 83% for distinguishing patients with early gastric cancer and healthy subjects,and 84.3%,78% and 86% for differentiating early gastric cancer and benign lesions.Conclusion The NLR and CA724 level are related to the degree of gastric lesions.The combination of NLR and serum CEA,CA199 and CA724 levels can improve the accuracy,sensitivity and specificity of detection and provide reference for the screening of early gastric cancer.