白细胞介素-17与白细胞介素-35在自身免疫性疾病中的研究进展

Research progress of interleukin-17 and interleukin-35 in autoimmune diseases

自身免疫性疾病是免疫耐受性破坏的结果,最终导致组织损伤,但病因尚未阐明。辅助性T细胞(Th17)、调节性T细胞(Treg)、Treg/Th17失衡及其相关细胞因子与自身免疫性疾病的发生发展密切相关。白细胞介素(IL)-17主要由Th17分泌,具有促炎效应,参与各种自身免疫性疾病发生发展。IL-35是IL-12家族的一种新型细胞因子,主要由Treg产生,具有免疫负性调节作用,是Th17/Treg相关的重要细胞因子。本文就IL-17与IL-35的功能、效应机制及其在自身免疫性疾病中的作用等进行综述,以为该病的治疗提供理论基础。

Autoimmune diseases are the outcomes of a breakdown of immune tolerance that eventually leads to tissue damage,but the etiology of which has not been elucidated.Helper T cells(Th17),regulatory T cells(Treg),Treg/Th17 imbalance and related cytokines are closely related to the occurrence and development of autoimmune diseases.Interleukin(IL)-17 mainly secreted by Th17,has a pro-inflammatory effect and is involved in the occurrence and development of various autoimmune diseases.IL-35 as an important cytokine related to Th17/Treg is a novel cytokine in the IL-12 family,is mainly produced by Treg and has a negative immunomodulatory effect.This article reviewed the function,mechanism and role of IL-17 and IL-35 in autoimmune diseases,in order to provide theoretical basis for the treatment of these diseases.