原子吸收分光光度法测定醋酸钠中铝的含量

Determination of aluminum in sodium acetate by atomic absorption spectrophotometry

目的建立原子吸收分光光度法测定醋酸钠中铝含量,为供制备透析用制剂药用辅料醋酸钠质量控制提供依据。方法样品超声30 min后加硝酸稀释,石墨炉原子吸收分光光度法测定,铝空心阴极灯,测定波长:309.3 nm,电流:15 mA,光谱狭缝宽度:0.5 nm,塞曼偏振背景校正,测量模式:峰面积,热进样温度:60℃,基体改进剂:0.1%硝酸镁,标准曲线计算。结果在该实验条件下,铝离子在5~40 ng/ml的浓度范围线性关系良好(r=1.0);检出限为0.547 ng/ml;定量限为1.825 ng/ml;平均回收率为107.81%(RSD=3.17%,n=6)。结论本方法准确度高、重复性好,可用于醋酸钠中铝离子的含量测定。

Objective To establish atomic absorption spectrophotometry for the determination of aluminum in sodium acetate and to provide a basis for the quality control of sodium acetate,a pharmaceutical excipient for dialysis preparations.Methods The samples were ultrasonicated for 30 min,diluted with nitric acid,and then determined by graphite furnace atomic absorption spectrometry.An aluminum hollow cathode lamp was used.The detection conditions were as follows:detection wavelength,309.3 nm;current,15 mA;spectral slit width,0.5 nm;Zeeman polarization background correction;measurement mode,peak area;thermal injection temperature,60℃;matrix modifier:0.1% magnesium nitrate.The standard curve was calculated.Results Under the experimental conditions,the linear relationship demonstrated by aluminum ion in the concentration range of 5 to 40 ng/ml was good(r=1.0).The limit of detection was 0.547 ng/ml;The limit of quantification was 1.825 ng/ml;The average recovery was 107.81%(RSD=3.17%,n=6).Conclusion The method shows high accuracy and good reproducibility,and can be used for the determination of aluminum ions in sodium ac etate.