肿瘤细胞衰老及相关治疗的研究进展

Study advances in tumor cell senescence and related therapies

细胞衰老是一种多效性的细胞状态,贯穿于机体生理及病理多重环节的始末,维持细胞与组织自身功能及结构的动态平衡。传统意义上,细胞衰老以永久性的增殖停滞为特征,以各种治疗手段加速肿瘤细胞衰老成为既往肿瘤治疗的一大理论基石,然而,近年来人们对于细胞衰老机制的探索不断深入,发现由于肿瘤微环境中的细胞衰老现象具有特殊的生物学特性,一些衰老肿瘤细胞甚至可以“重启”细胞周期,从而实现“重生”并获得更高的侵袭能力及治疗抵抗性。研究证实,这种现象与肿瘤治疗后复发有密切关联。本文将对肿瘤细胞衰老的相关机制进行归纳总结,并对其相关诱导及清除治疗的研究进展进行综述。

Cell senescence is a pleiotropic cellular state that runs through the beginning and end of multiple processes of body physiology and pathology,maintaining the dynamic balance of the functions and structures of cells and tissues.Traditionally,cell senescence is characterized by permanent proliferation stagnation,and accelerating tumor cell senescence by various therapeutic means has been a major theoretical cornerstone of tumor therapy in the past.However,in recent years,the exploration on cell senescence mechanisms has been deepened,and it has been found that some senescent tumor cells can even"restart"the cell cycle due to the special biological characteristics of cell senescence in the tumor microenvironment,thus achieving"rebirth"and higher invasion ability and therapeutic resistance.And this phenomenon has been proven to be closely related to tumor recurrence after treatment.This paper summarizes the mechanisms of tumor cell senescence and reviews the study advances in the senescence-inducing and eradication therapy.