布鲁氏菌的主要毒力因子及其致病机制

Research progress on prime virulence factors and pathogenesis of brucellosis

布鲁氏菌病(brucellosis),简称布病,是由布鲁氏菌(Brucella)感染所引起的一种人畜共患病,在世界范围内广泛流行,给我国公共卫生、畜牧业和社会经济的发展带来重大损失。然而,对于布病的特异性临床指征、布鲁氏菌的毒力因子以及其致病机制的了解非常有限,这导致临床上对布病的诊断和治疗具有一定的局限性。本文从布病的流行现状出发,重点阐述了布鲁氏菌的毒力因子及致病机制,综合概述了布病发病过程中布鲁氏菌在受感染机体内的活动轨迹和状态,为布病致病机制的深入研究提供新思路,并为疫苗的研发和临床诊疗提供全面参考。

Brucellosis is an infectious zoonosis caused by Brucella infection.It is widely prevalent all over the world and brings great losses to the development of public health,animal husbandry and social economy in China.However,the understanding of the specific clinical indications of brucellosis,the virulence factors of Brucella and its pathogenesis is very limited,which leads some limitations in the clinical diagnosis and treatment of brucellosis.Starting from the current epidemic situation of brucellosis,this article focuses on the virulence factors of Brucella and pathogenesis of brucellosis,and comprehensively summarizes the activity track and state of Brucella in the infected organism during the pathogenesis of brucellosis,so as to provide new ideas for the in-depth study of the pathogenesis of brucellosis,and a comprehensive reference for vaccine development and clinical diagnosis and treatment.