聚乙二醇脂质体多柔比星辅助治疗淋巴瘤的效果及对机体免疫功能的影响

Value of pegylated liposomal doxorubicin in the adjuvant treatment of patients with lymphoma and its effect on body’s immune function

目的:探究聚乙二醇脂质体多柔比星辅助治疗淋巴瘤的效果及对机体免疫功能的影响。方法:选取88例淋巴瘤患者,按照随机数字表法分为观察组与对照组,每组各44例。对照组采用多柔比星治疗,观察组采用聚乙二醇脂质体多柔比星治疗。比较两组临床疗效、血液指标、不良反应及免疫指标。结果:观察组总有效率68.18%明显高于对照组45.45%(P<0.05);治疗后,两组患者胆红素及谷丙转氨酶(ALT)水平均有所上升,白蛋白水平均有所下降,且观察组优于对照组,两组比较差异有统计学意义(P<0.05);观察组不良反应总发生率明显低于对照组(P<0.05);两组CD^(3+)、CD^(4+)、CD^(4+)/CD^(8+)水平均有上升,CD^(8+)水平有所下降,且观察组优于对照组,两组比较差异有统计学意义(P<0.05)。结论:聚乙二醇脂质体多柔比星辅助治疗淋巴瘤患者可改善免疫功能及肝功能,效果显著。

Objective:To explore the value of pegylated liposomal doxorubicin in the adjuvant treatment of patients with lymphoma and its influence on body's immune function.Methods:Totally 88 patients with lymphoma were randomized into 2 groups,each with 44 cases.The control group were treated with doxorubicin,while the observation group were given pegylated liposomal doxorubicin.The efficacy,blood indicators,adverse reactions and immune indicators were compared between the two groups.Results:The total effective rate of observation group was significantly higher than that of control group(P<0.05).After treatment,the levels of bilirubin and alanine aminotransferase(ALT)in the two groups were increased,while the level of albumin was decreased,and the indicators of observation group were better than those of control group,which were of statistical differences(P<0.05);the total incidence rate of adverse reactions in observation group was significantly lower than that in control group(P<0.05);and the levels of CD^(3+),CD^(4+) and CD^(4+)/CD^(8+) were increased,while the CD^(8+) level was reduced,and the indicators in observation group were better than those in control group,with significant differences(P<0.05).Conclusion:The adjuvant treatment of pegylated liposomal doxorubicin is more effective in treating patients with lymphoma,which can improve the immune function and liver function in patients.