细胞焦亡与细菌感染

Pyroptosis and Bacterial Infection

细胞焦亡是一种程序性细胞死亡方式,又称细胞炎性坏死,依赖于炎症小体形成和Gasdermin蛋白家族相关蛋白的作用。具体表现形式有别于细胞其他程序性死亡方式(凋亡、自噬和坏死)。细胞焦亡是机体重要的免疫防御机制,在清除病原体感染及内源性危险信号时发挥重要作用。因此,了解细胞焦亡分子病理机制及其在细菌感染过程中的作用有利于为相关疾病的治疗提供新的靶位,进一步指导临床实践。

Pyroptosis,also known as inflammatory necrosis of cells,is a type of programmed cell death that depends on the formation of Inflammasome and the role of related proteins in the Gasdermin protein family.The specific manifestation is different from other methods of programmed cell death(apoptosis,autophagy,and necrosis).Pyroptosis is an important immune defense mechanism of the body,which plays an important role in clearing pathogen infection and endogenous danger signals.Therefore,understanding the molecular pathological mechanism of pyroptosis and its role in the process of bacterial infection will help provide new targets for the treatment of related diseases and further guide clinical practice.