公英翘芦散对靶动物奶牛的安全性试验

Safety Test of Gongying Qiaolu Powder on Target Animal Dairy Cows

为考察公英翘芦散使用于靶动物奶牛的安全性及安全剂量范围,选取40头奶牛随机分为4组,每组10头,即1倍推荐剂量组、3倍推荐剂量组、5倍推荐剂量组和空白对照组,连续灌服药物7 d,每日1次,观察给药前后受试奶牛的精神、食欲及粪尿情况,并检测给药7 d、14 d后受试奶牛呼吸频率、心率、体温、血液学参数及生化指标。结果显示,受试奶牛胃管灌服公英翘芦散后,精神状态良好、食欲良好、体温、呼吸频率、心率、血液学指标及生化指标均未发现异常,与对照组相比,各项指标均无显著性差异(P>0.05)。结果表明,公英翘芦散在临床上1倍~5倍剂量使用时,无毒性反应,对于靶动物奶牛是安全可靠的。

In order to investigate the safety and safe dose range of Gongying Qiaolu Powder used in target animal dairy cows,this study selected 40 dairy cows and randomly divided them into 4 groups,each with 10 cows,that is,1 times the recommended dose group and 3 times the recommended dose group,5 times the recommended dose group and the blank control group.The drugs were given continuously for 7 days,once a day.The spirit,appetite,feces and urine of the tested cows before and after the administration were observed,and the breath rate,heart rate,body temperature,hematological parameters and biochemical indicators of dairy cows were tested 7 and 14 days after the administration.The results showed that the tested dairy cows had good mental state,good appetite,normal body temperature,respiratory rate,heart rate,hematology and biochemical indexes after gastric administration of Gongying Qiaolu Powder.Compared with the control group,all indexes were not abnormal,there was no significant difference(P>0.05).It shows that Gongying Qiaolu Powder has no toxic reaction when used 1-5 times doses clinically,and it is safe and reliable for target animal dairy cows.