布地奈德雾化吸入治疗小儿肺炎的效果探讨

Effects of budesonide aerosol inhalation in the treatment of infantile pneumonia

目的探讨布地奈德雾化吸入治疗小儿肺炎的临床效果。方法95例小儿肺炎患儿,采用随机数字表法分为对照组(47例)和研究组(48例)。对照组患儿采取常规治疗方法,研究组患儿在对照组基础上采用布地奈德雾化吸入治疗。对比两组患儿的治疗效果、肺炎症状缓解时间、不良反应发生率及治疗前后肺功能指标[呼气流量峰值(PEF)、用力肺活量(FVC)、第1秒用力呼气容积(FEV1)]、炎性因子指标[降钙素原(PCT)、白细胞介素-6(IL-6)、C反应蛋白(CRP)]。结果研究组患儿治疗总有效率95.8%显著高于对照组的83.0%,差异有统计学意义(P<0.05)。治疗后,研究组患儿PEF、FVC、FEV1均高于对照组,差异有统计学意义(P<0.05)。研究组患儿咳嗽、发热及肺部啰音缓解时间分别为(6.38±1.16)、(2.07±1.72)、(6.21±1.67)d,均显著短于对照组的(8.31±1.96)、(3.17±1.82)、(8.42±1.87)d,差异有统计学意义(P<0.05)。治疗后,研究组患儿PCT、IL-6、CRP均低于对照组,差异有统计学意义(P<0.05)。研究组患儿不良反应发生率4.2%低于对照组17.0%,差异有统计学意义(P<0.05)。结论对肺炎患儿采用布地奈德雾化吸入治疗效果更佳,可明显改善临床症状与炎性因子指标,提升肺功能,降低不良反应发生率,建议临床广泛应用。

Objective To discuss the clinical effects of budesonide aerosol inhalation in the treatment of infantile pneumonia.Methods 95 children with pneumonia were randomly divided into the control group(47 cases)and the study group(48 cases).The children in the control group were treated with conventional therapy,and the children in the study group were treated with budesonide aerosol inhalation in addition to that of the control group.The therapeutic effect,remission time of pneumonia symptoms,incidence of adverse reactions,pulmonary function indexes[peak expiratory flow(PEF),forced vital capacity(FVC),forced expiratory volume in the first second(FEV1)]and inflammatory factor indexes[procalcitonin(PCT),interleukin-6(IL-6),C-reactive protein(CRP)]before and after treatment were compared between the two groups.Results The overall efficacy of the study group was 95.8%,which was significantly higher than 83.0%of the control group;and the difference was statistically significant(P<0.05).After the treatment,PEF,FVC and FEV1 of the study group were significantly higher than those of the control group;and the differences were statistically significant(P<0.05).The remission time of cough,fever and pulmonary rales of the study group were(6.38±1.16)d,(2.07±1.72)d,(6.21±1.67)d respectively,which were significantly shorter than(8.31±1.96)d,(3.17±1.82)d,(8.42±1.87)d of the control group;and the differences were statistically significant(P<0.05).After the treatment,PCT,IL-6 and CRP of the study group were lower than those of the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions of the study group was 4.2%,which was significantly lower than 17.0%of the control group,and the difference was statistically significant(P<0.05).Conclusion Budesonide aerosol inhalation shows better therapeutic effects in the treatment of children with pneumonia.It can significantly improve the clinical symptoms,inflammatory factors and lung function,and reduce the incidence of adverse reactions.Thus,it is worthy of promotion in clinical practices.