氨氯地平阿托伐他汀钙片治疗冠心病的疗效及血脂水平变化分析

Therapeutic efficacy of amlodipine besylate and atorvastatin calcium tablets in the treatment of coronary heart disease and changes of blood lipid level

目的研究氨氯地平阿托伐他汀钙片治疗冠心病的临床效果。方法125例冠心病患者,利用电脑随机生成方法分为对照组(62例)和观察组(63例)。对照组采用氨氯地平治疗,观察组采用氨氯地平阿托伐他汀钙片治疗。比较两组治疗前后血脂水平、动脉硬化程度及心血管不良事件发生情况。结果治疗后,两组甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平均低于治疗前,高密度脂蛋白胆固醇(HDL-C)水平均高于治疗前,且观察组TG、TC、LDL-C水平均小于对照组,HDL-C水平高于对照组,差异具有统计学意义(P<0.05)。治疗后,两组颈动脉内膜中层厚度(IMT)均小于治疗前,肱动脉血流介导的血管内皮舒张功能(FMD)大于治疗前,且观察组IMT(1.11±0.18)mm小于对照组的(1.47±0.22)mm,FMD(11.13±1.25)%大于对照组的(9.87±0.94)%,差异具有统计学意义(P<0.05)。观察组心血管不良事件发生率明显低于对照组,差异具有统计学意义(P<0.05)。结论氨氯地平阿托伐他汀钙片治疗冠心病可更有效减低血脂水平,控制动脉硬化,减少心血管不良事件发生情况。

Objective To study the clinical effects of amlodipine besylate and atorvastatin calcium tablets in the treatment of coronary heart disease.Methods 125 patients with coronary heart disease were randomly divided into the control group(62 cases)and the observation group(63 cases).Patients of the control group were administrated with amlodipine,and patients of the observation group were administrated with amlodipine besylate and atorvastatin calcium tablets.The blood lipid level,degree of arteriosclerosis and occurrence of adverse cardiovascular events were compared between the two groups before and after treatment.Results After the treatment,the levels of triglyceride(TG),total cholesterol(TC)and low density lipoprotein cholesterol(LDL-C)of each group were lower than those before the treatment;the level of high density lipoprotein cholesterol(HDL-C)of each group after the treatment was higher than that before the treatment;and the levels of TG,TC and LDL-C of the observation group were lower than those of the control group;the level of HDL-C of the observation group was higher than that of the control group;and the differences were statistically significant(P<0.05).After the treatment,the carotid intima-media thickness(IMT)of each group was less than that before the treatment;the flow mediated dilatation(FMD)of brachial artery of each group was greater than that before the treatment;the IMT of the observation group was(1.11±0.18)mm,which was lower than(1.47±0.22)mm of the control group;and the FMD of the observation group was(11.13±1.25)%,which was higher than(9.87±0.94)%of the control group;and the differences were statistically significant(P<0.05).The incidence of cardiovascular adverse events of the observation group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Application of amlodipine besylate and atorvastatin calcium tablets in the treatment of coronary heart disease can effectively reduce blood lipid levels,control arteriosclerosis,and reduce the occurrence of adverse cardiovascular events.