卡前列甲酯栓联合缩宫素预防高危妊娠产后出血的临床效果观察

Clinical effect of carboprost methylate suppository combined with oxytocin in prevention of postpartum hemorrhage in high-risk pregnancy

目的观察卡前列甲酯栓联合缩宫素预防高危妊娠产后出血的临床效果。方法130例高危妊娠产妇,按产后出血预防方案分为单一组和联合组,各65例。单一组给予单一缩宫素进行预防,联合组给予卡前列甲酯栓联合缩宫素进行预防。比较两组产妇产后出血率、输血治疗率、用药不良反应发生率及产后2、24 h出血量。结果联合组产后出血率7.7%、输血治疗率4.6%均低于单一组的21.5%、18.5%,差异具有统计学意义(P<0.05);联合组用药不良反应发生率6.2%与单一组7.7%比较,差异无统计学意义(P>0.05)。联合组产后2、24 h出血量分别为(100.21±42.11)、(187.21±69.87)ml,均少于对照组的(157.43±52.45)、(321.21±78.43)ml,差异具有统计学意义(P<0.05)。结论卡前列甲酯栓、缩宫素联合应用可有效预防高危妊娠产后出血,可提高高危妊娠产妇的妊娠安全性,减少产后并发症发生,值得推广应用。

Objective To observe the clinical effect of carboprost methylate suppository combined with oxytocin in prevention of postpartum hemorrhage in high-risk pregnancy.Methods A total of 130 cases of highrisk pregnant women were divided into single group and combined group according to the prevention scheme of postpartum hemorrhage,with 65 cases in each group.The single group received single oxytocin for prevention,and the combined group received carboprost methylate suppository combined with oxytocin for prevention.The postpartum hemorrhage rate,blood transfusion rate,incidence of adverse drug reactions,and 2 and 24 h postpartum hemorrhage volume were compared between the two groups.Results The postpartum hemorrhage rate of the combined group was 7.7%,and the blood transfusion rate was 4.6%,which were lower than 21.5%and 18.5%of the single group,and the differences were statistically significant(P<0.05).The incidence of adverse drug reactions in the combined group was 6.2%,which was not statistically significant compared with 7.7%in the single group(P>0.05).The 2 and 24 h postpartum hemorrhage volume of the combined group were(100.21±42.11)and(187.21±69.87)ml,which were less than(157.43±52.45)and(321.21±78.43)ml of the control group,and the difference was statistically significant(P<0.05).Conclusion Carboprost methylate suppository combined with oxytocin can effectively prevent postpartum hemorrhage of high-risk pregnancy,improve the pregnancy safety of high-risk pregnant women,reduce the occurrence of postpartum complications,which is worthy of promotion and application.