儿童造血干细胞移植术后EB病毒感染的发生率及危险因素分析

Incidence and Risk Factors of Epstein Barr Virus Infection after Hematopoietic Stem Cell Transplantation in Children

目的:探讨儿童造血干细胞移植术后EB病毒感染的发生率及危险因素。方法回顾性分析2017年1月—2020年2月在样本医院行造血干细胞移植术治疗的168例患儿的临床资料,分析儿童造血干细胞移植术后EB病毒感染的发生率及危险因素。结果:168例患儿造血干细胞移植术EB病毒感染发生率为54.76%(92/168);多因素logistic回归分析,使用全身照射治疗(TBI)、移植物中CD34阳性细胞数≤3×10^(6)/个/kg是儿童造血干细胞移植术后EB病毒感染的独立危险因素,差异无统计学意义(P<0.05且OR≥1)。结论:儿童造血干细胞移植术后EB病毒感染发生率较高,使用TBI、移植物中CD34阳性细胞数≤3×10^(6)/个/kg是其发生的的高危因素,临床需加以重视。

Objective:To investigate the incidence and risk factors of Epstein Barr(EB)virus infection after hematopoietic stem cell transplantation in children.Methods:The clinical data of 168 children who underwent hematopoietic stem cell transplantation in the hospital from January 2017 to February 2020 were retrospectively analyzed.The incidence and risk factors of EB virus infection after hematopoietic stem cell transplantation in children were analyzed.Results:The incidence of EB virus infection in168 children undergoing hematopoietic stem cell transplantation was 54.76%(92/168).Multivariate logistic regression analysis showed that the use of total body irradiation(TBI)and the number of CD34 positive cells in the graft≤3×10^(6)/cell/kg were independent risk factors for Epstein-Barr virus infection after hematopoietic stem cell transplantation in children,the difference was not statistically significant(P<0.05 and OR≥1).Conclusion:The incidence of Epstein-Barr virus infection after hematopoietic stem cell transplantation in children is relatively high.The use of TBI and the number of CD34 positive cells in the transplant≤3×10^(6) cell/kg are high-risk factors,which need to be paid attention to in clinical practice.