养心氏片联合比索洛尔对冠心病稳定型心绞痛患者动态心电图指标及血液流变学的影响

Effect of Yangxinshi Tablet Combined with Bisoprolol on Ambulatory Electrocardiogram and Hemorheology in Patients with Stable Angina Pectoris of Coronary Heart Disease

目的:探讨养心氏片联合比索洛尔对冠心病稳定型心绞痛患者动态心电图指标及血液流变学的影响。方法:选取2018年6月—2019年9月河南科技大学第一附属医院收治的89例冠心病稳定型心绞痛患者作为研究对象,根据奇偶生成法分为对照组44例和观察组45例。予以对照组比索洛尔治疗,观察组在对照组基础上联合养心氏片治疗。治疗8周后,比较分析两组患者的临床疗效、中医证候积分、临床症状改善、心电图心率变异性[高频心率(HF)、低频心率(LF)、LF/HF]及血液流变学(纤维蛋白原、红细胞压积、血浆黏度和全血黏度)。结果:与对照组(72.73%)相比,观察组治疗总有效率(93.33%)更高,差异有统计学意义(χ^(2)=6.741,P<0.05);治疗前,两组患者中医证候积分、临床症状改善、心电图心率变异性及血液流变学指标对比,差异无统计学意义(t=0.359、0.872、0.895,P>0.05);治疗后,与对照组比较,观察组中医证候积分更低,心绞痛发作次数更少,且每次持续时间更短,差异有统计学意义(t=8.499、24.118、21.062,P<0.05);治疗后,观察组HF、LF、LF/HF高于对照组,差异有统计学意义(t=2.171、11.982、7.517,P<0.05);治疗后,与对照组相比,观察组血液流变学各项指标更低,差异有统计学意义(t=18.161、5.824、11.285、4.962,P<0.05)。结论:给予冠心病稳定型心绞痛患者养心氏片联合比索洛尔治疗,可有效提高治疗效果,改善心电图心率变异性,动态调节血液流变学,恢复心肌供血,改善临床症状,减少心绞痛的发作。

Objective:To investigate the effect of Yangxinshi tablet combined with bisoprolol on ambulatory electrocardiogram and hemorheology in patients with stable angina pectoris of coronary heart disease.Methods:A total of 89 patients with stable angina pectoris with coronary heart disease admitted to the hospital from June 2018 to September 2019 were selected as the research objects,and divided into the control group(44 cases)and the observation group(45 cases)according to the odd-even method.The control group was treated with bisoprolol,and the observation group was treated with Yangxinshi tablet on this basis.After 8 weeks of treatment,the clinical efficacy,TCM syndrome score,improvement of clinical symptoms,ECG heart rate variability(high frequency heart rate[HF],low frequency heart rate[LF],LF/HF)and hemorheology(fibrinogen,hematocrit,plasma viscosity and whole blood viscosity)of the two groups were compared and analyzed.Results:Compared with the control group(72.73%),the total effective rate of the observation group(93.33%)was higher,and the difference was statistically significant(χ^(2)=6.741,P<0.05).Before treatment,there was no statistically significant difference in TCM syndrome scores,clinical symptoms improvement,ECG heart rate variability and hemorheology indexes between the two groups(t=0.359,0.872,0.895,P<0.05).After treatment,compared with the control group,the observation group had lower TCM syndrome scores,fewer episodes of angina pectoris,and each time duration was shorter,and the differences were statistically significant(t=8.499,24.118,21.062,P<0.05).After treatment,HF,LF and LF/HF in the observation group were higher than those in the control group,and the differences were statistically significant(t=2.171,11.982,7.517,P<0.05).After treatment,compared with the control group,the hemorheology indexes of the observation group were lower,and the difference was statistically significant(t=18.161,5.824,11.285,4.962,P<0.05).Conclusion:Yangxinshi tablet combined with bisoprolol can effectively improve the therapeutic effect,effectively improve the heart rate variability of ECG,dynamically regulate hemorheology,restore myocardial blood supply,improve clinical symptoms and reduce the attack of angina pectoris.