D⁃二聚体、CEA、SCC⁃Ag与非小细胞肺癌关系研究进展

Research progress on the relationship between D-dimer,CEA,SCC-Ag and non-small cell lung cancer

多数恶性肿瘤患者存在凝血异常,D-二聚体是多种凝血纤溶指标中与肺癌进展密切相关的指标。癌胚抗原(carcinoembryonic antigen,CEA)是内胚层细胞分化而来的癌症细胞表面的一种酸性糖蛋白,在非小细胞肺癌(non-small cell lung cancer,NSCLC)的诊断中应用颇为广泛,是最早用于肺癌诊断的肿瘤标志物之一。鳞状上皮细胞癌抗原(squamous cell carcinoma antigen,SCC-Ag)是鳞状上皮细胞癌细胞浆的一种糖蛋白,研究表明,SCC-Ag对诊断NSCLC有较高的特异性,其水平的高低与肿瘤的进展相关。多种肿瘤标志物联合检测对提高肺癌诊断准确性已取得一定成果,但少有将凝血指标与肿瘤标志物联合来评估其对诊断NSCLC的临床意义。因此,本文对D-二聚体、CEA、SCC-Ag与NSCLC关系的研究进展作一综述,以期提高对NSCLC的检出率,开拓NSCLC诊断的新思路。

Most patients with malignant tumors have disturbance of blood coagulation,and D-dimer is one of many coagulation and fibrinolysis indexes that have the closest correlation with the disease progression of lung cancer patients. CEA is an acidic glycoprotein on the surface of cancer cells derived from the differentiation of endodermal cells,which is widely used in non-small cell lung cancer(NSCLC)and one of the earliest tumor markers for lung cancer diagnosis. SCC-Ag is a glycoprotein present in the cytoplasm of squamous cell carcinoma. Many studies have shown that SCC-Ag has a high specificity for the diagnosis of NSCLC,and its level is related to tumor progression. Combined detection of multiple tumor markers has achieved some results in improving the diagnosis of lung cancer. However,the combination of coagulation indicators and tumor markers is rarely used to evaluate the clinical significance of the diagnosis of NSCLC. In order to further clarify the relationship about whether the combination of the two can improve the diagnostic value of NSCLC and serve as a new way to diagnose NSCLC,in this paper we review the research progress of the relationship between D-dimer,CEA,SCC-Ag and NSCLCby searching a large number of literatures. .