miRNAs与脊髓损伤后小胶质细胞的交互作用

Cross-talk between miRNAs and microglia after spinal cord injury

脊髓损伤(spinal cord injury,SCI)是一类主要由外力引起脊柱骨折或脱位而导致的脊髓损坏,其进展过程主要分为原发性损伤和继发性损伤两个阶段。在继发性损伤阶段,小胶质细胞对疾病发展和转归起着重要作用,其通过自身活化、诱发炎症反应、改变自身极化状态来调节中枢损伤微环境。miRNAs是一类微小非编码RNA,其主要通过靶向调控下游基因来发挥生物学效能,从而参与脊髓损伤的病理发展。miRNA与小胶质细胞的交互作用对促进脊髓损伤后中枢神经系统修复有重要意义。本文就脊髓损伤后miRNAs对小胶质细胞的影响进行综述。

Spinal cord injury(SCI)is a spinal damage mainly caused by spinal fracture or dislocation which induced by external force.Its progression process is mainly divided into two stages:primary injury and secondary injury.During secondary injury,microglia play an important role in the development and prognosis of disease.They regulate the microenvironment of central injury through self-activation,inducing inflammatory response and microglial polarization.miRNAs are a kind of micro noncoding RNAs,which play a biological role mainly through targeting and regulating downstream genes,participating in the pathological development of SCI.The cross-talk between miRNA and microglia is of great significance to promote the repair of central nervous system after spinal cord injury.In this article,we reviewed the effect of miRNAs on microglia after spinal cord injury to provide some ideas for clinical diagnosis and treatment.