“融合”学说:胆固醇、炎症与动脉粥样硬化的新视野

Joint hypothesis:a novel concept of cholesterol,inflammation,and atherosclerosis

动脉粥样硬化(AS)之胆固醇学说已深入人心,炎症作为AS发病的重要机制之一也倍受关注。新近Nature杂志刊出哈佛大学Peter Libby教授的文章,其核心学术思想之一是将AS的胆固醇理论和炎症学说“融合”一体,认为二者缺一不可。作者读后颇有感悟,草起此文,与读者共享。

It is well-known that atherosclerosis(AS)is a cholesterol-mediated disease,strongly associated with inflammation,to which close attention is widely paid.More recently,an interesting paper written by Peter Libby,a professor at Harvard University,was published in Nature.One of the core academic points is the combined theory of cholesterol and inflammation in the development of AS.I have several reactions after reading this wonderful manuscript and now present them in this journal to enjoy it with others.