β-Ⅰ型胶原羧基端肽、血清铁蛋白水平与脆性骨折的相关性研究

Correlation between β-CTX,serum ferritin and brittle fracture

目的探讨β-Ⅰ型胶原羧基端肽(β-CTX)、血清铁蛋白(SF)水平与脆性骨折的相关性。方法选取该院2016年1月至2021年1月收治的80例脆性骨折患者纳入脆性骨折组,另选取同期来该院体检的80例骨质疏松未出现骨折的患者为骨质疏松组,80例骨质正常者作为对照组。对比3组研究对象β-CTX、SF水平,并分析β-CTX、SF水平与脆性骨折的相关性。根据80例脆性骨折患者预后情况分为预后良好组、预后不良组,对比相关临床指标,并分析β-CTX、SF对脆性骨折预后的预测价值。结果3组患者β-CTX、SF水平比较,差异有统计学意义(P<0.05),脆性骨折组β-CTX、SF水平明显高于骨质疏松组与对照组(P<0.05);Spearman相关分析结果显示,β-CTX、SF水平与脆性骨折呈正相关(P<0.05);预后良好组与预后不良组患者性别、年龄、体质量指数、基础疾病比较,差异无统计学意义(P>0.05),两组患者骨折史、营养供给不足患者所占比例,以及β-CTX、SF水平比较,差异有统计学意义(P<0.05)。Logistic回归分析结果表明,骨折史、β-CTX、SF为脆性骨折患者预后的独立危险因素(P<0.05)。结论β-CTX、SF水平与脆性骨折具有相关性,且能预测脆性骨折患者预后不良。这提示β-CTX、SF水平升高者为脆性骨折高风险人群与术后不良预后人群。该研究为脆性骨折预防提供了参考。

Objective To explore the correlation between β-type Ⅰ collagen carboxy terminal peptide(β-CTX)and serum ferritin(SF)with fragility fracture.Methods Eighty cases of fragility fracture in this hospital from January 2016 to January 2021 were selected as the fragility fracture group,contemporaneous 80 patients undergoing physical examination with osteoporosis without fracture served as the osteoporosis group and 80 subjects with normal bone substance served as the control group.The levels of β-CTX and SF were compared among the three groups,and the correlation between β-CTX and SF with fragility fracture was analyzed.Eighty patients with fragility fracture were divided into the good prognosis group and poor prognosis group according to the prognosis.The relevant clinical indicators were compared,and the predictive value of β-CTX and SF for fragility fracture was analyzed.Results There were statistically significant differences in β-CTX and SF levels among the three groups(P<0.05),the β-CTX and SF levels in the fragelity fracture group were significantly higher than those in the osteoporosis group and control group(P<0.05);the Spearman correlation analysis results showed that the levels of β-CTX and SF were positively correlated with fragility fracture(P<0.05);there were no statistically significant differences in gender,age,body mass index and underlying diseases between the good prognosis group and the poor prognosis group(P>0.05),but there were statistically significant differences in the fracture history,proportion of patients with nutritional supply deficiency,β-CTX and SF levels between the two groups(P<0.05).The Logistic regression analysis results showed that the fracture history,β-CTX and SF were the independent risk factors for the prognosis of the patients with fragility fracture.Conclusion The levels of β-CTX and SF are correlated with fragility fracture,moreover could predict the poor prognosis of the patients with fragility fracture,which suggests that the patients with β-CTX and SF expression levels increase are the high risk population of fragility fracture and postoperative poor prognosis.This study provides the reference for the prevention of fragility fracture.