奥利司他胶囊联合二甲双胍治疗肥胖2型糖尿病患者的疗效及安全性

Efficacy and Safety of Orlistat Capsules Combined with Metformin in Treatment of Obese Patients with Type 2 Diabetes Mellitus

目的:探讨奥利司他胶囊联合二甲双胍在肥胖2型糖尿病患者治疗中的疗效及安全性。方法:选取2019年1月至2020年12月肥胖2型糖尿病患者114例,随机分为两组,对照组使用二甲双胍治疗,研究组使用奥利司他联合二甲双胍治疗。比较两组体质量指数、体质量、血脂变化情况、血糖水平变化情况和不良反应情况。结果:两组治疗后体质量指数、体质量均低于治疗前(P<0.05),与对照组相比,研究组体质量指数、体质量均更低(P<0.05);两组治疗后低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、三酰甘油(TG)水平均低于治疗前,高密度脂蛋白胆固醇(HDL-C)均高于治疗前(P<0.05),且研究组LDL-C、TC、TG水平均低于对照组,HDL-C高于对照组(P<0.05);两组治疗后糖化血红蛋白(HbA1c)、餐后2 h血糖(2 hPG)、FPG水平均低于治疗前(P<0.05),且研究组HbA1c、2 hPG、空腹血糖(FPG)水平均低于对照组(P<0.05);两组间恶心、呕吐、鼻咽炎、低血糖、腹泻合计不良反应发生率差异无统计学意义(P>0.05)。结论:肥胖2型糖尿病患者使用奥利司他联合二甲双胍治疗,患者体质量可获得较大减少,体质量、血糖、血脂可获得有效控制、改善,具有显著的治疗疗效,值得临床推广。

Objective:To explore the efficacy and safety of orlistat capsules combined with metformin in the treatment of obese type 2 diabetic patients.Methods:From January 2019 to December 2020,114 obese patients with type 2 diabetes were randomly divided into two groups.The control group was treated with metformin,while the study group was treated with orlistat combined with metformin.The changes of body mass index,body weight,blood lipid,blood glucose level and adverse reactions were compared between the two groups.Results:The body mass index and body weight of the two groups after treatment were lower than those before treatment(P<0.05),compared with the control group,the body mass index and body weight of the study group were lower(P<0.05).After treatment,the levels of LDL-C,TC and TG in the two groups were lower than those before treatment,and the levels of HDL-C were higher than those before treatment(P<0.05),the levels of LDL-C,TC and TG in the study group were lower than those in the control group,and the levels of HDL-C were higher than those in the control group(P<0.05).The levels of HbA1c,2 hPG and FPG in the two groups after treatment were lower than those before treatment(P<0.05);the levels of HbA1c,2 hPG and FPG in the study group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of nausea,vomiting,nasopharyngitis,hypoglycemia and diarrhea between the two groups(P>0.05).Conclusion:The use of orlistat combined with metformin in obese patients with type 2 diabetes can significantly reduce the body mass.Body weight,blood sugar and blood lipids can be effectively controlled and improved.