丙戊酸抗乳腺癌作用研究进展

Research progress of valproic acid on breast cancer

目的对近年来关于丙戊酸抗乳腺癌方面的相关研究做一综述,为进一步研究丙戊酸抗乳腺癌的作用机制,以及丙戊酸在治疗乳腺癌方面的临床应用提供参考。方法通过在中国知网、Pubmed、GeenMedical等数据库检索国内外关于丙戊酸抗乳腺癌的相关文献并对文献内容进行归纳总结。结果分析多篇文献可以发现,丙戊酸可以分别通过不同机制对乳腺癌产生抑制作用,具体机制包括诱导细胞周期停滞和凋亡,抑制细胞迁移,以及影响乳腺癌干细胞等。此外丙戊酸还可以通过干扰DNA修复途径作为乳腺癌治疗的放射增敏剂,并且可作为乳腺癌化疗的协同药物。结论丙戊酸可以从多方面抑制乳腺癌,这为乳腺癌靶向治疗提供了新的研究方向。

Objective To review the relevant research of valproic acid on the anti-breast cancer in recent years,so as to provide reference for further research on the mechanism of valproic acid against breast cancer and the clinical application of valproic acid in the treatment of breast cancer.Methods It was finished by searching domestic and foreign related literatures on valproic acid against breast cancer in databases such as CNKI,Pubmed,GeenMedical,and summarizing the content of the literature.Results It was found that valproic acid can inhibit breast cancer through different mechanisms by analyzing of numerous literatures,inducing cell cycle arrest and apoptosis,inhibiting cell migration,and affecting breast cancer stem cells.In addition,valproic acid was also used as a radiosensitizer for breast cancer treatment by interfering with DNA repair pathways,and was used as a synergistic drug for breast cancer chemotherapy.Conclusion Valproic acid can inhibit breast cancer in many ways,which provides a new research direction for breast cancer targeted therapy.