恩诺沙星悬乳剂肌注给药在鸡体内的药动学研究

The Pharmacokinetics of Enrofloxacin and Its Metabolite in Chickens

为研究恩诺沙星悬乳剂在来航鸡体内的动力学,以肌注给药后利用RP-HPLC法测定鸡血浆中恩诺沙星浓度,恩诺沙星Ci-Ti数据采用MCPKP药物动力学计算机程序进行处理。肌注恩诺沙星后的Ci-Ti数据符合一级吸收二室开放性模型,其药代动力学参数T_(1/2α)、T_(1/2β)、V_(d)、CLB和AUC分别为0.25±0.04 h、5.26±0.81 h、4.53±1.07 L/kg、0.61±0.11 L/kg·h、17.39±3.92μg/mL·h;试验结论显示鸡注射恩诺沙星后,在体内分布广泛,血药维持时间长、消除缓慢,有较好的临床应用前景。

The pharmacokinetic characteristics of enrofloxacin was studied in healthy broilers.Plasma concentrations of enrofloxacin was determined by a reversed phase high-performance liquid chromatography.The data of enrofloxacin in plasma were analysed with MCPKP program and the data of metabolite in plasma were calculated with metabolite kinetics method.The results showed that the Ci-Ti data of enrofloxacin in plasma after intravenous administration in healthy broilers are fitted to a two-compart-ment open model.The main pharmacokinetic parameters are as follows:T_(1/2α)(0.25±0.04)h,T_(1/2β)(5.26±0.81)h,V_(d)(4.53±1.07)L/kg,CLB(0.61±0.11)L/(kg·h),AUC(17.39±3.92)μg/mL·h.In a conclusion,the enrofloxacin has good clinical application prospect。