内皮细胞能量代谢与病理性血管生成

Endothelial cell energy metabolism and pathological angiogenesis

血管生成是指从已有的毛细血管或毛细血管后静脉发展而形成新的血管,是各种生理和病理环境中的关键事件。近年来,内皮细胞代谢在病理性血管生成中的作用受到了广泛关注。越来越多的研究表明,内皮细胞血管生成开关和病理性血管生成受到能量代谢关键因子的调控。内皮细胞独特的糖酵解特性对细胞的增殖、迁移和对环境变化的反应至关重要。该文概述了内皮细胞能量代谢的最新研究,并总结和讨论了利用内皮细胞代谢的潜在治疗策略,为靶向内皮细胞代谢的药物开发提供一定的参考。

Angiogenesis,the formation of new blood vessels from the development of existing capillaries or posterior capillary veins,is a key event in various physiological and pathological environments.In recent years,the role of endothelial cell metabolism in pathological angiogenesis has attracted much attention.More and more studies have shown that endothelial angiogenesis switches and pathological angiogenesis are regulated by key factors of energy metabolism.The unique glycolysis properties of endothelial cells are essential for cell proliferation,migration and response to environmental changes.In this review,we provide an overview of recent research on endothelial cell energy metabolism and summarize and discuss the potential therapeutic strategies using endothelial cell metabolism to provide some reference for drug development targeting endothelial cell metabolism.