儿童急性淋巴细胞白血病合并血栓栓塞研究进展

The research progress of acute lymphoblastic leukemia with thromboembolism in children

急性淋巴细胞白血病(ALL)是儿童最常见的恶性血液系统疾病,也是最常见的合并血栓的恶性肿瘤。血栓栓塞和患儿凝血功能异常与化疗药物、感染、深静脉置管以及遗传因素等有关,严重者可危及生命。文章就ALL患儿血栓栓塞的发生机制、临床特点、危险因素及治疗进展进行综述,以提高对儿童ALL合并血栓栓塞的认识。

Acute lymphoblastic leukemia (ALL) is the commonest hematological malignancy in children,and also the commonest malignant tumor associated with thrombosis.Thromboembolism and abnormal coagulation function in children are related to chemotherapy drugs,infection,deep vein catheterization and genetic factors,and can endanger life in severe cases.This article reviewed the pathogenesis,clinical characteristics,risk factors and treatment progress of thromboembolism in children with ALL,in order to improve the understanding of thromboembolism in children with ALL.