摘要
ES-62(excretory secretory-62)是源自魏氏棘唇线虫(Acanthocheilonema viteae)排泄分泌物中的一种由磷酰胆碱修饰的四聚体糖蛋白,可通过诱导树突状细胞、单核-巨噬细胞和调节性B细胞等免疫细胞耐受介导免疫调节反应,以预防或治疗免疫失调性疾病。近年来,ES-62蛋白在过敏性、自身免疫性及代谢性疾病等多种免疫失调性疾病中的作用成为研究热点。本文综述了ES-62蛋白在各种免疫失调性疾病中的调节作用及相关机制,为进一步研究提供理论依据及实验参考。
ES-62 is a phosphorylcholine-containing, 62 kDa glycoprotein derived from the excretory-secretory product of Acanthocheilonema viteae, which is effective for the prevention and treatment of immune dysregulation diseases through triggering activation of immune cells, such as dendritic cells, mononuclear macrophages and regulatory B cells and mediating immune responses. Recently, the role of the ES-62 protein in the management of allergic, autoimmune and metabolic diseases has been paid much attention. This review summarizes the regulatory role of the ES-62 protein in immune dysregulation diseases and the underlying mechanisms, so as to provide insights into future experimental studies.
作者
胡琪
邢敬雨
吴培
黄婷婷
杨小迪
HU Qi;XING Jing-yu;WU Pei;HUANG Ting-ting;YANG Xiao-di(Anhui Provincial Key Laboratory of Infection and Immunity,Bengbu Medical College,Bengbu,Anhui 233030,China;Department of Microbiology and Parasitology,Bengbu Medical College,Bengbu,Anhui 233030,China)
出处
《中国血吸虫病防治杂志》
CAS
CSCD
北大核心
2022年第2期204-211,共8页
Chinese Journal of Schistosomiasis Control
基金
安徽省高校学科(专业)拔尖人才学术资助项目(gxbjZD15)
蚌埠医学院自然科学高层次科技项目立项攀登计划(2020bypd007)
蚌埠医学院“512人才培育计划”(by51201205)
蚌埠市-蚌埠医学院联合科技攻关项目(BYLK201818)
安徽省卫生健康委科研重点项目(AHWJ2021a005)
安徽省教育厅重点自然科学研究项目(KJ2019A0383)
蚌埠医学院研究生科研创新计划(Byycxz20015)
国家级大学生创新训练项目(202010367006、201910367002)
安徽省自然科学基金(2008085MH260)。
关键词
魏氏棘唇线虫
排泄分泌物
ES-62
免疫失调性疾病
Acanthocheilonema viteae
Excretory-secretory product
ES-62
Immune dysregulation diseases
