加减芍药汤合云南红药直肠滴入对溃疡性结肠炎活动期临床效果分析

Clinical effect analysis of modified Shaoyao Decoction and Yunnan Hongyao rectal dripping on ulcerative colitis in active stage

目的探讨加减芍药汤合云南红药直肠滴入治疗溃疡性结肠炎(UC)活动期的临床效果。方法选取2019年8月至2021年9月抚州市中医院收治的70例UC活动期患者作为研究对象,采用交替分组法将其分为对照组与研究组,每组各35例。对照组患者采用常规治疗,研究组患者在对照组的基础上采用加减芍药汤合云南红药直肠滴入治疗,两组均治疗4周。比较两组患者的中医证候评分、改良Mayo评分、Baron内镜评分、血清C-反应蛋白、乳酸杆菌、双歧杆菌及不良反应发生情况。结果治疗4周后,研究组患者的中医证候评分、改良Mayo评分及Baron内镜评分低于对照组,差异有统计学意义(P<0.05)。治疗4周后,研究组患者的血清C-反应蛋白水平低于对照组,乳酸杆菌、双歧杆菌计数高于对照组,差异有统计学意义(P<0.05)。两组患者治疗期间均未发生明显不良反应。结论加减芍药汤合云南红药直肠滴入治疗可降低UC活动期患者的改良Mayo评分、Baron内镜评分及炎症因子水平,改善患者肠道菌群,减轻患者临床症状,且安全性好。

Objective To investigate the clinical effect of modified Shaoyao Decoction and Yunnan Hongyao rectal on the active stage of ulcerative colitis(UC).Methods A total of 70 UC patients admitted to Fuzhou Hospital of Traditional Chinese Medicine from August 2019 to September 2021 were selected as the research objects,and they were divided into control group and study group by alternate grouping method,with 35 patients in each group.Control group was treated with conventional treatment,and research group was treated with modified Shaoyao Decoction and Yunnan Hongyao rectal dripping on the basis of control group.Both groups were treated for 4 weeks.The traditional Chinese medicine syndrome score,modified Mayo score,Baron endoscopy score,serum C-reactive protein,lactobacillus,bifidobacteria and the incidence of adverse reactions were compared between the two groups.Results After 4 weeks of treatment,traditional Chinese medicine syndrome score,modified Mayo score and Baron endoscopy score of the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After 4 weeks of treatment,the level of serum C-reactive protein in the study group was lower than that in the control group,while the counts of Lactobacillus and Bifidobacteria were higher than those in the control group,and the differences were statistically significant(P<0.05).There were no obvious adverse reactions in the two groups during treatment.Conclusion Modified Shaoyao Decoction combined with Yunnan Hongyao rectal infusion can reduce the modified Mayo score,Baron endoscopy score and inflammatory factor levels in patients with active UC,improve the intestinal flora of the patients,reduce the clinical symptoms of the patients,and have good safety.