摘要
A copper-catalyzed three-component reaction of alkenes,cycloketone oximes and DABCO·(SO_(2))_(2) is de-veloped,which provides a convenient route for the synthesis of diverse(E)-cyanoalkylsulfonyl alkenes in moderate to good yields with excellent regio-and stereoselectivity.A broad substrate scope with ex-cellent functional group tolerance is observed.A plausible radical pathway is proposed,which involves copper-catalyzed ring-opening C–C bond cleavage of O-acyl oxime and insertion of sulfur dioxide.During the reaction process,cyanoalkyl radical and cyanoalkylsulfonyl radical are the key intermediates.
基金
support from the National Natural Science Foundation of China (No. 21871053)
the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang (No. 2019R01005)
the Open Research Fund of School of Chemistry and Chemical Engineering, Henan Normal University (No. 2020ZD04) is gratefully acknowledged
