摘要
The Beckmann rearrangement has been predominantly studied for the synthesis of amide and lactam.By strategically using the in situ generated Appel’s salt or Mitsunobu’s zwitterionic adduct as the de-hydrating agent,a series of Beckmann rearrangement and following cascade reactions have been devel-oped herein.The protocol allows the conversion of various ketoximes into amide,thioamide,tetrazole and imide products in modular procedures.The generality and tolerance of functionalities of this method have been demonstrated.
基金
supported by National Key Research and Development Project (No. 2021YFC2100100)
National Natural Science Foundation of China (No. 21901123)
Natural Science Foundation of Jiangsu Province (No. BK20190694)
Jiangsu Specially Appointed Professor Plan
