男性不育与泌尿系肿瘤的相关性研究进展

Male infertility and urologic cancers:Advances in studies

男性不育症是男科门诊中较常见的疾病之一。相关研究证明,男性生育能力受损与肿瘤的发生率和死亡率有显著相关性,尤其是泌尿生殖系统恶性肿瘤,如睾丸癌和前列腺癌。男性不育与恶性肿瘤之间的联系是多方面的,主要包括染色体异常、基因突变、表观遗传标记改变、激素水平失衡、先天畸形等。同时,各种慢性疾病也被证实与男性不育存在显著关联,精液质量或生育能力状态可能是男性整体健康的生物标志物。深入研究男性不育与这些领域的内在联系,对理解疾病的发病机制、预防疾病的发生至关重要。

Male infertility is one of the most common diseases in andrology.Studies show that male infertility is significantly correlated with the incidence and mortality of tumors,especially malignant tumors in the genitourinary system,such as testis cancer and prostate cancer.The relationship of male infertility with genitourinary system tumors involves various aspects,mainly including changes in chromosome mutations,epigenetic marks,hormonal imbalance,and congenital deformity.Besides,some chronic diseases are shown to be significantly associated with male infertility,and semen quality or fertility status may be biomarkers of the overall health of males.In-depth studies of the correlation between male infertility and these factors are very important for an insight into the pathogenesis and prevention of the related diseases.