2型糖尿病患者血尿酸水平变化与检验价值分析

Changes of serum uric acid level in patients with type 2 diabetes mellitus and its testing value

目的分析2型糖尿病患者血尿酸水平变化与检验价值。方法纳入100例2型糖尿病患者作为观察组,另抽取100例健康体检人员作为对照组,两组均进行血尿酸检验,对比血尿酸与肌酐、胆固醇、甘油三酯的关系,并分析血尿酸水平变化对并发症的影响。结果观察组血尿酸(480.45±60.21)μmol/L高于对照组的(393.11±38.93)μmol/L,差异有统计学意义(P<0.05)。观察组高尿酸血症发生率36.00%高于对照组的7.00%,差异有统计学意义(P<0.05)。2型糖尿病高血尿酸患者肌酐、胆固醇、甘油三酯均高于正常血尿酸患者,差异有统计学意义(P<0.05)。2型糖尿病高血尿酸患者并发症发生率为88.89%(32/36),高于正常血尿酸患者的46.88%(30/64),差异有统计学意义(P<0.05)。结论2型糖尿病血尿酸升高的几率较健康人群高,而血尿酸升高增加了动脉粥样硬化的风险,因此2型糖尿病患者在血糖、血脂控制的同时,还需要加强血尿酸控制,减少并发症的出现。

Objective To analyze the changes of serum uric acid level in patients with type 2 diabetes mellitus and its testing value.Methods 100 patients with type 2 diabetes mellitus were selected as the observation group,and another 100 healthy subjects were selected as the control group.Both groups were tested for blood uric acid to compare the correlation between serum uric acid and creatinine,cholesterol,and triglyceride,and analyze the effect of serum uric acid level changes on complications.Results The serum uric acid(480.45±60.21)μmol/L in the observation group was higher than(393.11±38.93)μmol/L in the control group,and the difference was statistically significant(P<0.05).The incidence of hyperuricemia in the observation group was 36.00%,which was higher than 7.00%in the control group,and the difference was statistically significant(P<0.05).The creatinine,cholesterol and triglyceride of patients with type 2 diabetes mellitus and hyperuricemia were higher than those of patients with normal serum uric acid,and the difference was statistically significant(P<0.05).The complication rate of patients with type 2 diabetes and hyperuricemia was 88.89%(32/36),which was higher than 46.88%(30/64)of patients with normal serum uric acid,and the difference was statistically significant(P<0.05).Conclusion The probability of elevated serum uric acid in type 2 diabetes mellitus is higher than that in healthy people,and elevated serum uric acid increases the risk of atherosclerosis.Therefore,in the control of blood glucose and blood lipids,patients with type 2 diabetes mellitus need to strengthen the control of serum uric acid to reduce the occurrence of complications.