博路定治疗慢性乙型重型肝炎的疗效研究

Study on the efficacy of Baraclude in the treatment of chronic severe hepatitis B

目的研究恩替卡韦片(商品名:博路定)治疗慢性乙型重型肝炎患者的临床效果。方法68例慢性乙型重型肝炎患者,按照随机数字表法分为对照组和研究组,每组34例。对照组实施传统保肝及对症支持治疗,研究组在对照组基础上实施博路定治疗。对比两组治疗前后肝功能指标及并发症发生情况。结果研究组并发症发生率14.71%低于对照组的41.18%,差异有统计学意义(P<0.05)。治疗前,两组总胆红素、丙氨酸氨基转移酶、白蛋白水平及凝血酶原活动度对比,差异无统计学意义(P>0.05);治疗后,研究组总胆红素水平(51.22±20.89)μmol/L、丙氨酸氨基转移酶水平(75.11±40.68)U/L均低于对照组的(90.76±25.10)μmol/L、(107.11±42.56)U/L,白蛋白水平(35.45±3.63)g/L及凝血酶原活动度(42.63±20.10)%均高于对照组的(31.89±3.82)g/L、(30.45±18.63)%,差异有统计学意义(P<0.05)。结论对慢性乙型重型肝炎患者应用博路定治疗可促进肝功能改善,而且可以降低并发症发生率,临床价值显著。

Objective To study the clinical effect of entecavir tablets(trade name:Baraclude)in the treatment of chronic severe hepatitis B.Methods A total of 68 patients with chronic severe hepatitis B were divided into control group and research group according to random numerical table,with 34 cases in each group.The control group received traditional liver protection and symptomatic and supportive treatment,while the research group received Baraclude treatment on the basis of the control group.The liver function indexes before and after treatment and complications were compared between the two groups.Results The complication rate 14.71%in the research group was lower than 41.18%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in total bilirubin,alanine aminotransferase,albumin levels and prothrombin activity(P>0.05).After treatment,the total bilirubin(51.22±20.89)μmol/L and alanine aminotransferase(75.11±40.68)U/L in the research group were lower than(90.76±25.10)μmol/L and(107.11±42.56)U/L in the control group,and the albumin(35.45±3.63)g/L and prothrombin activity(42.63±20.10)%were higher than(31.89±3.82)g/L and(30.45±18.63)%in the control group.All the differences were statistically significant(P<0.05).Conclusion For patients with chronic severe hepatitis B,the application of Baraclude can promote the improvement of liver function,and avoid the occurrence complication rate,which has significant clinical value.