垂盆草配方颗粒联合谷胱甘肽治疗HBV阳性妊娠肝功能异常的疗效观察

Observation on efficacy of sedum sarmentosum granules combined with glutathione in the treatment of the HBV-positive pregnant women with abnormal liver function

目的观察垂盆草配方颗粒联合谷胱甘肽治疗乙型肝炎病毒(HBV)阳性妊娠肝功能异常的临床疗效。方法52例HBV阳性妊娠肝功能异常患者作为本次研究对象,按用药情况不同分为对照组及试验组,每组26例。对照组使用谷胱甘肽片治疗,试验组在对照组的基础上联合垂盆草配方颗粒治疗。比较两组患者的临床疗效及治疗前后的肝功能指标[谷草转氨酶(AST)、谷丙转氨酶(ALT)]水平。结果治疗后,试验组患者的总有效率65.4%高于对照组的34.6%,差异具有统计学意义(P<0.05)。治疗后,试验组患者的AST(49.27±27.01)U/L、ALT(65.73±39.20)U/L低于本组治疗前的(71.65±44.78)、(102.38±51.93)U/L,差异具有统计学意义(P<0.05);对照组患者的AST、ALT水平与本组治疗前比较,差异无统计学意义(P>0.05)。试验组患者治疗后的ALT水平低于对照组的(109.12±78.34)U/L,差异具有统计学意义(P<0.05);两组患者治疗后的AST水平比较,差异无统计学意义(P>0.05)。结论垂盆草配方颗粒联合谷胱甘肽能有效改善HBV阳性妊娠肝功能异常患者的肝功能,临床疗效较好,值得推广使用。

Objective To observe the clinical efficacy of sedum sarmentosum granules combined with glutathione in the treatment of the hepatitis B virus(HBV)-positive pregnant women with abnormal liver function.Methods A total of 52 cases of HBV-positive pregnant patients with abnormal liver function were selected as the subjects of this study.They were divided into control group and experimental group according to their medication situation,with 26 cases in each group.The control group was treated with glutathione tablets,and the experimental group was treated with sedum sarmentosum granules on the basis of the control group.The clinical efficacy,liver function indexes[aspartate aminotransferase(AST),alanine aminotransferase(ALT)]levels before and after treatment were compared between the two groups.Results After treatment,the total effective rate 65.4%in the experimental group was higher than 34.6%in the control group,and the difference was statistically significant(P<0.05).After treatment,the AST(49.27±27.01)U/L and ALT(65.73±39.20)U/L in the experimental group were lower than(71.65±44.78)and(102.38±51.93)U/L before treatment,and the differences were statistically significant(P<0.05).There was no statistically significant difference in AST and ALT levels in the control group compared with those before treatment in this group(P>0.05).After treatment,the ALT level of the experimental group was lower than(109.12±78.34)U/L of the control group,and the difference was statistically significant(P<0.05).After treatment,there was no statistically significant difference in AST level between the two groups(P>0.05).Conclusion Sedum sarmentosum granules combined with glutathione can effectively improve the liver function of HBV-positive pregnant women with abnormal liver function with good clinical efficacy,and is worthy of promotion and application.