枸橼酸咖啡因在早产儿原发性呼吸暂停治疗中的临床疗效及安全性探讨

Clinical efficacy and safety of caffeine citrate in the treatment of premature infants with primary apnea

目的探讨枸橼酸咖啡因在早产儿原发性呼吸暂停治疗中的临床疗效及安全性。方法50例原发性呼吸暂停早产儿,根据治疗方法的不同分为参照组和观察组,各25例。参照组采用氨茶碱进行治疗,观察组采用枸橼酸咖啡因注射液进行治疗。比较两组患儿临床指标及不良反应发生情况。结果观察组患儿治疗3 d后呼吸暂停发作次数(0.94±0.21)次/d少于参照组的(4.71±0.58)次/d,持续用药时间(4.71±1.23)d、呼吸暂停消失时间(3.89±0.71)d、给氧治疗时间(4.17±1.56)d均显著短于参照组的(8.14±1.75)、(7.57±1.23)、(9.32±1.13)d,差异均有统计学意义(P<0.05)。观察组的不良反应发生率为4.00%,低于参照组的32.00%,差异具有统计学意义(P<0.05)。结论原发性呼吸暂停早产儿应用枸橼酸咖啡因,可以保证治疗效果,并降低不良反应的发生几率,从而取得理想的治疗效果,因此,值得临床推广应用。

Objective To discuss the clinical efficacy and safety of caffeine citrate in the treatment of premature infants with primary apnea.Methods A total of 50 cases of premature infants with primary apnea were divided into reference group and observation group according to different treatment methods,with 25 cases in each group.The reference group was treated with aminophylline,and the observation group was treated with caffeine citrate injection.The clinical indicators and occurrence of adverse reactions were compared between the two groups.Results After 3 d of treatment,the number of episodes of apnea(0.94±0.21)times/d in the observation group was less than(4.71±0.58)times/d in the reference group,and the duration of medication(4.71±1.23)d,apnea disappearance time(3.89±0.71)d and duration of oxygen therapy(4.17±1.56)d were significantly shorter than(8.14±1.75),(7.57±1.23),and(9.32±1.13)d of the reference group.All the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 4.00%,which was lower than 32.00%in the reference group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of premature infants with primary apnea,the application of caffeine citrate can ensure the therapeutic effect and reduce the probability of adverse reactions,so as to achieve the ideal therapeutic effect.Therefore,this treatment method is worthy of clinical promotion and application.