脓毒症相关肝损伤发生机制的最新进展

Recent Progress in Pathogenesis of Sepsis Related Liver Injury

脓毒症常由外源性感染引起,具有发病率高、可引起器官损伤等特点,多见于重症医学。近年来随着对脓毒症研究的深入,脓毒症相关肝损伤(SRLI)也引起了临床医师的关注。肝脏在脓毒症发生的病理生理过程中扮演着重要角色,既参与免疫防御,也可引起免疫炎症风暴,加剧感染,同时炎症也会造成肝脏损伤,进而导致SRLI。目前临床上缺乏SRLI明确的诊断标准,对于SRLI的发生机制尚不明确。对SRLI的发病机制进行深入研究具有重要的临床诊断及治疗价值,有助于临床上尽早展开治疗,从而改善SRLI患者预后。

Sepsis is usually caused by exogenous infection and has the characteristics of high incidence and organ damage,which is mostly seen in critical care medicine.In recent years,with the deepening of research on sepsis,sepsis related liver injury(SRLI)has also attracted the attention of the clinicians.Liver plays an important role in the pathophysiological process of the development of sepsis,which not only participates in immune defense,but also can cause immune inflammatory storm and aggravate infection.At the same time,inflammation can also cause liver damage and lead to SRLI.At present,there is a lack of clear diagnostic criteria for SRLI in clinical practice,and the pathogenesis of SRLI is still not well studied.In-depth study of the pathogenesis of SRLI has great value for the clinical diagnosis and treatment,which is conducive to the early clinical treatment,so as to improve the prognosis of SRLI patients.