我国结核病防治相关医务工作者结核分枝杆菌潜伏感染现况的Meta分析

Latent tuberculosis infection among TB-related health-care workers in China:a Meta-analysis

目的了解我国结核相关岗位医务工作者的结核感染状态,为建立针对医务工作者结核感染状态监测及防控措施政策提供依据。方法在中、英文文献数据库中以标准化检索式检索在我国范围内针对结核防治相关岗位医务工作者结核潜伏感染情况研究的相关文献,根据纳入排除标准对搜索结果进行研读和筛选,提取感染率数据后进行Meta分析。结果共纳入30篇文献,采用随机效应模型对三种检测方法所得感染率进行效应合并,得到T-SPOT、QFT和TST(≥10 mm)三种方法检测结核感染率分别为29.53%(95%CI:24.26%~35.08%)、41.07%(95%CI:28.81%~53.92%)和43.44%(95%CI:31.49%~55.78%)。结论我国结核相关医务工作者结核感染情况严重,亟需出台针对性的感染监测和防病措施,以保障医务工作者的健康。

Objective To analyze the current situation of tuberculosis infection among TB-related health-care workers in China,and to provide evidence to make suggestion for the corresponding prevention and control strategies.Methods Searching for studies concerning latent tuberculosis infection status among TB-related health-care workers in China using a systematic searching strategy on Chinese and English literature databases.All the articles were read and filtered based on inclusion and exclusion criteria.Data were extracted from eligible literatures for Meta-analysis and other statistical analysis.Results 30 literatures were included.Meta-analysis by random effect model provided an overall LTBI infection rate stratified by testing method of T-SPOT,QFT and TST(≥10 mm),which are 29.53%(95%CI:24.26%-35.08%),41.07%(95%CI:28.81%-53.92%),and 43.44%(95%CI:31.49%-55.78%)respectively.Conclusions The TB infection rate among health-care workers in China is much higher comparing to general population.Targeted infection surveillance and prevention measures are urgently needed to safeguard the health of health-care workers.