维生素D在糖尿病周围神经病变中的作用研究进展

Research progress on the role of vitamin D in diabetic peripheral neuropathy

维生素D(Vit D)是脂溶性的类固醇激素,其经典作用包括调节钙磷代谢、促进骨骼生长、调节细胞增殖、生长分化及调节免疫功能等。糖尿病周围神经病变(DPN)患者中普遍存在Vti D缺乏的现象。适量补充Vit D对延缓DPN病程可起到积极作用,其机制可能与Vit D具有调节糖脂代谢、保护胰岛β细胞功能、减轻氧化应激、抗炎及保护血管内皮细胞功能有关。本文就Vit D在DPN中的作用进行了综述,以期为DPN的治疗提供新的途径。

Vitamin D(Vit D)is a fat-soluble steroid hormone,whose classical effects include regulating calcium and phosphorus metabolism,promoting bone growth,regulating cell proliferation,growth and differentiation,and regulating immune function.Vti D deficiency is common among patients with diabetic peripheral neuropathy(DPN).Adequate supplementation of Vit D can delay the process of DPN,and the mechanism may be related to the effects of regulating glucose and lipid metabolism,protecting the function of pancreaticβcells,reducing oxidative stress,anti-inflammatory and protecting the function of vascular endothelial cells of Vit D.This paper reviews the role of Vit D in DPN in order to provide a new way for the treatment of DPN.