基于全暴露组关联分析技术的环境健康研究进展

Research progress on environmental health based on exposome-wide association study

暴露组是整个生命周期中历经的所有暴露.为了更好地评估暴露组-疾病的关联,参照全基因组关联研究的概念(GWAS),提出了全暴露组关联分析(EWAS).全暴露组关联分析是一种数据驱动的探索性研究方法,可用于发现与某些复杂疾病相关联的环境因素.文章搜索并纳入了当前的全暴露组关联分析文章,从研究对象、暴露变量、流行病学结局和统计分析几个方面总结了文章的研究方法,综述了目前的研究进展,提炼研究的特点和当前局限,并对其未来做出展望.

The exposome represents the totality of environmental exposures received by a person during life.To investigate the environmental causes for disease,the exposome-wide association study(EWAS)was proposed based on the concept of the genome-wide association study(GWAS).EWAS is a data-driven,exploratory research method that can be used to identify specific environmental exposures associated with complex diseases.In this article,current articles on EWAS were searched,and the research methods of EWAS were summarized from the aspects of research objects,exposures,outcomes and statistical analysis.Meanwhile,the current progresses,features and limitations of EWAS were reviewed,and the prospect of future research on EWAS was put forward.