丙种球蛋白治疗川崎病患儿的效果及对抗血小板聚集相关因子免疫功能的影响

Effect of Gamma Globulin on Immune Function of Antiplatelet Aggregation Related Factors in Children with Kawasaki Disease

目的研究丙种球蛋白治疗川崎病(KD)患儿的效果及对抗血小板聚集相关因子及免疫功能的影响。方法选取2019年11月-2021年10月北京市顺义区医院儿科收治的72例KD患儿,按照随机数字表法分为对照组与观察组,每组36例。对照组给予阿司匹林治疗,观察组在对照组基础上联合丙种球蛋白治疗。比较两组症状消退时间、住院时间、炎症因子[C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)]、抗血小板聚集相关因子[血小板计数(PLT)、白细胞计数(WBC)、红细胞沉降率(ESR)]、免疫功能指标(CD3^(+)、CD4^(+)、CD8^(+))。结果观察组症状消退时间及住院时间短于对照组(P<0.05);观察组CRP、TNF-α、PLT、WBC、ESR、CD4^(+)低于对照组,CD3^(+)、CD8^(+)高于对照组(P<0.05)。结论丙种球蛋白可缩短KD患儿的康复时间,下调炎症反应,提高患儿的抗血小板聚集作用及免疫功能。

Objective To study the effect of gamma globulin in the treatment of children with Kawasaki disease(KD)and its effect on platelet aggregation related factors and immune function.Methods A total of 72 children with KD admitted to Department of Pediatrics of Shunyi District Hospital of Beijing from November 2019 to October 2021 were randomly divided into control group and observation group,with 36 cases in each group.The control group was treated with aspirin,and the observation group was treated with gamma globulin on the basis of the control group.The symptom regression time,hospitalization time,inflammatory factors[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)],anti-platelet aggregation related factors[platelet count(PLT),white blood cell count(WBC)and erythrocyte sedimentation rate(ESR)],immune function indexes(CD3^(+),CD4^(+),CD8^(+))were compared between the two groups.Results The symptoms subsided time and hospitalization time in the observation group were shorter than those in the control group(P<0.05).The levels of CRP,TNF-α,PLT,WBC,ESR and CD4^(+)in the observation group were lower than those in the control group,and CD3^(+)and CD8^(+)were higher than those in the control group(P<0.05).Conclusion Gamma globulin can shorten the recovery time of children with KD,down-regulate inflammation,and improve the anti-platelet aggregation effect and immune function.