丁酸盐在炎症性肠病中的作用研究进展

Research progress on the role of butyrate in inflammatory bowel disease

短链脂肪酸(short-chain fatty acids,SCFAs)是肠道菌群的代谢产物,SCFAs中的丁酸盐是肠道中重要的免疫调节分子,与肠道稳态关系密切。丁酸盐被证实可以改善肠屏障完整性,抗炎、诱导细胞自噬、调节肠道菌群失调、维持厌氧微环境及促进肠肝轴能量代谢。然而高浓度的丁酸盐会产生相反的作用,且在肠道活动性炎症及屏障损伤的患者中丁酸盐不能发挥作用。

Short-chain fatty acids(SCFAs)are metabolites of intestinal flora.Butyrate in SCFAs is an important immunomodulatory molecule in the intestinal tract,which is closely related to intestinal homeostasis.Butyrate has been shown to improve intestinal barrier integrity,mediate anti-inflammatory effects,induce autophagy,regulate intestinal flora imbalance,maintain anaerobic microenvironment,and promote enterohepatic axis energy metabolism.However,high concentrations of butyrate have the opposite effect,and they do not play a role in patients with active intestinal inflammation and barrier damage.