晚期糖基化终末产物在幽门螺杆菌感染所致胃癌患者中的情况及其与患者预后的相关性

Status of advanced glycation end products in patients with gastric cancer caused by Helicobacter pylori infection and its correlation with patients′prognosis

目的探讨晚期糖基化终末产物(AGE)在幽门螺杆菌(H.pylori)感染所致胃癌患者中的情况及其与患者预后的相关性。方法选择87例H.pylori感染所致的胃癌患者作为研究对象,所有患者均行手术治疗,术中取病灶组织及癌旁组织(距离病灶≥3 cm),并对患者进行12个月的术后随访。采用免疫组织化学法检测病灶组织与癌旁组织中AGE蛋白的表达阳性率,分析不同病理状态与病灶组织中AGE表达情况的关系,以及AGE表达情况与患者预后的关系。结果H.pylori感染所致胃癌患者病灶组织中AGE蛋白的表达阳性率为55.17%,高于癌旁组织的4.60%(P<0.05);H.pylori感染所致胃癌患者AGE蛋白表达情况与肿瘤大小、分化类型、肿瘤分期、淋巴结转移有关(均P<0.05);AGE蛋白表达阳性患者的生存期短于AGE蛋白表达阴性患者(P<0.05)。结论AGE在H.pylori感染所致胃癌患者中呈高表达水平,其表达水平能反映患者疾病的严重程度,且与患者预后相关。

Objective To explore the status of advanced glycation end products(AGE) in patients with gastric cancer caused by Helicobacter pylori(H. pylori) infection and its correlation with patients′ prognosis. Methods Eighty-seven patients with gastric cancer caused by H. pylori infection were selected as research subjects. All patients underwent surgical treatment, and lesion tissues and paracancerous tissues(≥3 cm from the lesion) were harvested during the operation;besides, the patients were followed up for 12 months after the operation. Immunohistochemistry assay was used to determine the positive rates of AGE protein expression in lesion tissues and paracancerous tissues. An analysis was performed on the correlation between various pathological states and AGE expression in lesion tissues, as well as the correlation between AGE expression and patients′ prognosis. Results The positive rate of AGE protein expression in lesion tissues of patients with gastric cancer caused by H. pylori infection was 55.17%, which was higher than the 4.60% in paracancerous tissues(P<0.05). The expression of AGE protein was related to tumor size, differentiation type, tumor stage, and lymph node metastasis in patients with gastric cancer caused by H. pylori infection(all P<0.05). The survival time of patients with positive expression of AGE protein was shorter than that of patients with negative expression of AGE protein(P<0.05). Conclusion AGE are highly expressed in patients with gastric cancer caused by H. pylori infection, and their expression levels can reflect the severity of the disease and correlate with the prognosis of the patients.