新癀片致药品不良反应分析

Thirty-six cases of adverse drug reactions/events caused by Xinhuang tablets

目的对新癀片不良反应(ADR)发生情况进行回顾分析,为临床合理用药提供参考。方法以“新癀片”“不良反应”“引起”“致”为检索词,检索中国知网、万方数据、维普网,检索时间为建库至2020年4月30日,对收录的新癀片ADR文献进行筛选和分析。结果研究纳入文献24篇,涉及病例36例,新癀片ADR累及系统-器官最常见的为神经系统损害、胃肠损害、全身性损害,主要ADR表现为恶心、呕吐、头晕、头痛、胸闷等,严重者可见过敏性休克。结论关注新癀片ADR,加强临床合理用药指导,确保用药安全。

Objective To retrospectively analyze ADR induced by Xinhuang tablets in order to provide reference for rational use of this drug in clinic.Methods With"Xinhuang tablets","adverse reaction"or"cause"as the key words,related articles were retrieved from the CNKI,Wanfang database and VIP Chinese full-text database that had been published from the inception to April 30,2020.Literature related to ADR induced by Xinhuang tablets was screened and analyzed.Results Twenty-four articles were included,involving 36 cases of adverse drug reactions.The dominating adverse reactions were manifested as neurological damage,gastrointestinal damage and systemic damage.Common symptoms included nausea,vomiting,dizziness,headache and chest distress.Anaphylactic shock,which was life threatening,was also reported in severe cases.Conclusion It is important that clinicians and patients become aware of ADR induced by Xinhuang tablets.Precaution should be taken to ensure the safe use of this drug.