不同中医证型寻常性银屑病患者睡眠质量、瘙痒程度与病情严重程度的相关性研究

Study on the relationship between sleep quality,itching degree,and severity of psoriasis vulgaris patients with different traditional Chinese medicine syndromes

目的探讨不同中医证型寻常性银屑病患者睡眠质量、瘙痒程度与病情严重程度的相关性。方法选取2021年2月至9月北京中医药大学东直门医院门诊就诊的寻常性银屑病患者112例,根据中医辩证分型将其分为血热组、血瘀组和血燥组,采用睡眠质量指数量表(PSQI)、失眠严重程度指数量表(ISI)、视觉模拟评分(VAS)及银屑病面积与严重性指数(PASI)量表进行调查。另选同期体检的健康人112名为对照组。结果与血热组比较,血瘀组ISI、VAS评分较低,血燥组PSQI、PASI、VAS评分较低(P<0.05);与血瘀组比较,血燥组PASI评分较低(P<0.05)。血热组主观睡眠质量、入睡时间和睡眠效率评分高于对照组(P<0.05);其中,血热组、血瘀组和血燥组睡眠时间评分高于对照组(P<0.05);血热阻睡眠障碍评分高于血瘀组和对照组(P<0.05);血热组日间功能障碍评分高于血瘀组和对照组,血燥组日间功能障碍评分低于血热组和对照组(P<0.05)。血热组的PSQI、VAS评分与PASI评分呈正相关(P<0.05)。结论不同中医证型的睡眠质量、瘙痒程度及病情严重程度不尽相同。血燥证以改善睡眠质量为主、血热证以缓解瘙痒为主、血瘀证以治疗原发病为主,可取得较好疗效。

Objective To investigate the correlation between sleep quality,itching degree,and severity of psoriasis vulgaris patients with different traditional Chinese medicine syndromes.Methods From February to September 2021,112 patients with psoriasis vulgaris were selected from the outpatient department of Dongzhimen Hospital of Beijing University of Chinese Medicine,they were divided into blood heat group,blood stasis group,and blood dryness group according to the dialectical classification of traditional Chinese medicine.They were investigated by sleep quality index(PSQI),insomnia severity index(ISI),visual analogue scales(VAS),and psoriasis area and severity index(PASI).Another 112 healthy volunteers were selected as the control group.Results Compared with blood heat group,ISI,and VAS scores were lower in blood stasis group,PSQI,PASI,and VAS scores were lower in blood dryness group(P<0.05).Compared with blood stasis group,PASI score in blood dryness group was lower(P<0.05).The subjective sleep quality,sleep time,and sleep efficiency scores of blood heat group were higher than those of control group(P<0.05).The sleep time scores of blood heat group,blood stasis group,and blood dryness group were higher than those of control group(P<0.05).The sleep disturbance score of blood heat group was higher than that of blood stasis group and control group(P<0.05).The daytime dysfunction score of blood heat group was higher than that of blood stasis group and control group,and the daytime dysfunction score of blood dryness group was lower than that of blood heat group and control group(P<0.05).PSQI,VAS scores were positively correlated with PASI scores in blood heat group(P<0.05).Conclusion Different traditional Chinese medicine syndromes have different sleep quality,pruritus degree,and severity of disease.Blood dryness syndrome mainly to improve sleep quality,blood heat syndrome mainly to relieve pruritus,blood stasis syndrome mainly to treat the primary disease,could achieve better curative effect.