基于CiteSpace和VOSviewer的肝癌干细胞研究的文献计量学分析

Bibliometric analysis of the research of liver cancer stem cell based on CiteSpace and VOSviewer

目的通过肝癌干细胞(LCSCs)进行文献计量学分析,探索近10年LCSCs领域的研究热点和研究趋势。方法基于Web of Science核心数据库,通过CiteSpace和VOSviewer对2011—2020年发表文章的年度分布、国家、机构、作者、期刊、被引情况和关键词等进行可视化分析,并对关键词的词频、中心性和聚类情况进行探讨。结果2011—2020年LCSCs相关文献发表量为1000篇,LCSCs相关文献发文量总体呈增长趋势;发文量前5位的国家分别是中国、美国、日本、韩国和意大利;发文量前5位的研究机构分别是第二军医大学、中山大学、复旦大学、香港大学和上海交通大学;发文量前5位的作者分别是Stephanie Ma、Taro Yamashita、Jia Fan、Hongyang Wang和Shuichi Kaneko;发文量前5位的期刊分别是Oncotarget、Hepatology、Cancer letters、PLoS One和Scientific Reports;被引文献中,Taro等2009年发表的“EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features”被引频次最高;LCSCs鉴定的干性标志物的研究,调控LCSCs的转录因子、长链非编码RNA、微小RNAs、癌基因和信号通路的研究等是LCSCs领域研究的热点;LCSCs干性研究-靶向LCSCs治疗研究-LCSCs生物学机制研究是LCSCs的研究趋势,靶向LCSCs的抑制剂研究是LCSCs的重点研究方向。结论调控LCSCs的基因和信号通路的研究是LCSCs领域的研究热点,靶向LCSCs的药物研究是LCSCs领域的重点研究方向。

Objective To explore the research hotspots and research trends in the field of liver cancer stem cells(LCSCs)in the past 10 years through the bibliometric analysis of LCSCs.Methods The annual distribution of articles published,countries,institutions,authors,journals,cited situation,and keywords of articles published from 2011 to 2020 were performed visual analysis through CiteSpace and VOSviewer based on the Web of Science core database.Results From 2011 to 2020,the number of LCSCs-related articles published was 1000,and the number of LCSCs-related articles published showed an overall increasing trend.The top five countries in the number of published articles were China,United States,Japan,South Korea,and Italy.The top five research institutions in the number of published articles were Second Military Medical University,Sun Yat-sen University,Fudan University,University of Hong Kong,and Shanghai Jiao Tong University.The top five authors in the number of published articles were Stephanie Ma,Taro Yamashita,Jia Fan,Hongyang Wang,and Shuichi Kaneko.The top five publications in the number of published articles were Oncotarget,Hepatology,Cancer Letters,PLoS One,and Scientific Reports.In the cited literatures,Taro,etc.2009 published“EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features”was cited the most frequently;studies on dry markers identified by LCSCs,studies on transcription factors,long non-coding RNA,microRNAs,oncogenes,signaling pathways that regulate LCSCs and other sides were the research hotspots in the field of LCSCs;LCSCs stem research-targeted LCSCs therapy research-LCSCs biological mechanism research was the research trend of LCSCs,the research on inhibitors targeting LCSCs was the focus of LCSCs research.Conclusion The research of genes and signal pathways regulating LCSCs is a research hotspot in the field of LCSCs,and the research of drugs targeted LCSCs is a key research direction in the field of LCSCs.