鼻咽癌组织中TRIM59、PPM1B的表达及临床意义

Expression and clinical significance of TRIM59 and PPM1B in nasopharyngeal carcinoma tissues

目的研究鼻咽癌(NPC)组织中三结构域蛋白59(TRIM59)、蛋白磷酸酶1B(PPM1B)的表达及临床意义。方法收集2014年2月至2018年2月四川省遂宁市中心医院诊治的97例NPC患者,免疫组织化学染色法检测癌组织和癌旁组织中TRIM59、PPM1B的表达;分析两者的关系及与临床特征的关系。Kaplan-Meier生存曲线分析TRIM59、PPM1B对NPC患者预后的影响。结果与癌旁组织比较,癌组织中TRIM59阳性表达率较高(P<0.05),而PPM1B阳性表达率较低(P<0.05)。TRIM59与PPM1B表达呈负相关(r=-0.524,P<0.01)。Ⅲ~Ⅳ期、淋巴结转移的NPC患者TRIM59阳性表达率、PPM1B阴性表达率高于Ⅰ~Ⅱ期、无淋巴结转移的NPC患者(P<0.05)。TRIM59阳性表达者3年生存率低于TRIM59阴性表达者(P<0.05);PPM1B阳性表达者3年生存率高于PPM1B阳性表达者(P<0.05)。结论NPC中TRIM59表达上调,而PPM1B表达下调,两者表达与肿瘤TNM分期及淋巴结转移有关,在鼻咽癌预后评估上有一定临床意义。

Objective To study the expression and clinical significance of tripartite motif-containing 59(TRIM59)and protein phosphatase 1B(PPM1B)in nasopharyngeal carcinoma(NPC)tissues.Methods A total of 97 NPC patients diagnosed and treated in Suining Central Hospital of Sichuan Province from February 2014 to February 2018 were collected,the expressions of TRIM59 and PPM1B in cancer tissues and adjacent tissues of NPC patients were detected by immunohistochemistry,and the relationship between them and clinical features were analyzed.The effects of TRIM59 and PPM1B on the prognosis of NPC patients were used to Kaplan-Meier survival curve.Results Compared with adjacent tissues,the positive rate of TRIM59 expression in cancer tissues was higher(P<0.05),while the positive rate of PPM1B expression was lower(P<0.05).The expression of TRIM59 and PPM1B was negatively correlated(r=-0.524,P<0.01).The positive expression rate of TRIM59 and the negative expression rate of PPM1B in NPC patients with stageⅢ-Ⅳ,lymph node metastasis were higher than those in NPC patients with stageⅠ-Ⅱ,without lymph node metastasis(P<0.05).The 3-year survival rate of TRIM59 positive expression was lower than that of TRIM59 negative expression(P<0.05);the 3-year survival rate of PPM1B positive expression was higher than that of PPM1B positive expression(P<0.05).Conclusion The expression of TRIM59 in NPC is up-regulated,while the expression of PPM1B is down-regulated.Both expressions are related to tumor TNM staging and lymph node metastasis,and have certain clinical significance in prognosis evaluation of nasopharyngeal carcinoma.