通脉养心丸治疗女性原发性稳定型微血管心绞痛的临床研究

Clinical study of Tongmai Yangxin Pills in the treatment of female primary stable microvascular angina

目的 评价通脉养心丸对女性原发性稳定型微血管心绞痛(MVA)的临床效果。方法 选取2015年6月至2020年6月河北医科大学沧州市中心医院首次确诊为原发性稳定型MVA的女性患者577例,通过随机数字表法分为对照组(288例)和通脉养心丸组(289例)。对照组给予常规冠心病药物治疗,通脉养心丸组在对照组的基础上加服通脉养心丸。对所有患者进行6个月的临床随访,比较两组临床显效率与有效率、再住院率及不良反应发生率,比较两组治疗前后加拿大心血管学会(CCS)心绞痛分级和心电图运动试验阳性率。结果 通脉养心丸组临床疗效优于对照组(P <0.05)。治疗后两组CCS心绞痛分级低于治疗前,且通脉养心丸组低于对照组(P <0.05)。治疗后两组心电图运动试验阳性率均低于治疗前,且通脉养心丸组低于对照组(P <0.05)。通脉养心丸组再住院率低于对照组(P <0.05)。两组不良反应发生率比较,差异无统计学意义(P> 0.05)。结论 通脉养心丸治疗女性原发性稳定型MVA的临床效果显著。

Objective To evaluate the clinical effect of Tongmai Yangxin Pills on female primary stable microvascular angina(MVA). Methods A total of 577 female patients who were first diagnosed with primary stable MVA in Cangzhou Central Hospital of Hebei Medical University from June 2015 to June 2020 were selected. They were divided into control group(288 cases) and Tongmai Yangxin Pills group(289 cases) by random number table method. The control group was given conventional drug treatment for coronary heart disease, and Tongmai Yangxin Pills group was given Tongmai Yangxin Pills on the basis of control group. All patients were followed up for six months, the significant effective rate and effective rate, rehospitalization rate, and incidence of adverse reaction between two groups were compared, grading of angina by Canadian Society of Cardiology(CCS) and positive rate of electrocardiogram exercise test before and after treatment between two groups were compared. Results The clinical effect in Tongmai Yangxin Pills group was better than that in control group(P < 0.05). After treatment, the grading of angina by CCS in the two groups was lower than that before treatment, and which in Tongmai Yangxin Pills group was lower than that in the control group(P < 0.05).After treatment, the positive rate of electrocardiogram exercise test in both groups was lower than that before treatment,and which in Tongmai Yangxin Pills group was lower than that in control group(P < 0.05). The rehospitalization rate of Tongmai Yangxin Pills group was lower than that in control group(P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P > 0.05). Conclusion Tongmai Yangxin Pills has a significant clinical effect on female patients with primary stable MVA.