E2F8在恶性肿瘤中的作用及机制研究进展

Research progresses on the roles and mechanisms of E2F8 transcription factor in cancers

E2F8是较晚发现的E2F转录子家族成员。它参与调控细胞周期、细胞增殖、分化、细胞凋亡以及DNA损伤修复。有研究提示,E2F8参与恶性肿瘤的发生发展,在多种恶性肿瘤中表达水平升高,并且其转录水平与肿瘤病人的不良预后密切相关。因此,E2F8有望成为恶性肿瘤的诊断标志物或治疗新靶点。这篇综述总结了近几年有关E2F8在恶性肿瘤中的作用及其机制研究的新进展,以期为恶性肿瘤的临床诊断和治疗提供参考依据。

E2F8 is a relatively new member of the E2F transcription factor family.It plays important roles in the regulation of cell cycle as well as cell proliferation,differentiation,cell apoptosis and DNA damage repairs.Recent studies have implicated E2F8 in the occurrence and development of various types of cancers.It is highly expressed in multiple cancers and its transcript levels are positively correlated with poor prognosis,suggesting that it could be either a biomarker or a novel therapeutic target for cancer.This review summarizes the latest research progresses on the roles and potential mechanisms of E2F8 in cancer,and may provide scientific basis for diagnosis and treatment of cancer.