慢性肾病与中医体质相关性的Meta分析

Meta-analysis of the Correlation between Chronic Kidney Disease and Constitution of TCM

目的通过分析慢性肾病中医体质类型的分布情况,探讨慢性肾病与中医体质的相关性。方法计算机检索中国期刊全文数据库(CNKI)、万方(WANFANG DATA)、中文科技期刊数据库(VIP)、中国生物医学数据库(CBM)、Medline、Embase、The Cochrane Library。收集整理慢性肾病中医体质类型病例对照研究。以Revman 5.3和Stata16软件为工具进行异质性、偏移风险检验与单组率的Meta分析,所有结果以95%可信区间表达效应值。结果共纳入11项病例对照研究,慢性肾病患者总计1685例,健康人群总计1300例。其中气虚质(29.82%)>血瘀质(22.13%)>阴虚质(21.53%)>湿热质(10.95%)。其他6种体质在慢性肾病人群的分布及占有率均小于10%。结论慢性肾病的发生、发展与气虚、血瘀及阴虚体质的关系最为密切。上述结论可能受纳入原始文献数量和质量等因素限制,而存在偏倚风险,有待进一步深入研究。

Objective To discuss the correlation between chronic kidney disease(CKD)and TCM constitution by analyzing the distribution of CKD TCM constitutional types.Methods Relevant information was extracted with computer retrieval from the Chinese National Knowledge Infrastructure(CNKI),WANFANG DATA,China Science and Technology Journal Database(VIP),China Biomedical Database(CBM),Medline,Embase,and The Cochrane Library.Controlled study was conducted by collecting cases with CKD TCM connotational types.Revman 5.3 and Stata16 software were used as tools to analyze the heterogeneity,offset risk tests and Meta-analysis of single group rate,and effect values were expressed with 95%confidence intervals for all outcomes.Results A total of 11 case-control studies were included,with a total of 1685 CKD patients and 1300 healthy people.Among them,there were 29.82%patients with Qi deficiency constitution,ranked first;22.13%with blood stasis,ranked second;21.53%with Yin deficiency,ranked third;and 10.95%with dampness-heat,ranked last.The distribution and share of the other six constitution types in the CKD population were all less than 10%.Conclusion The occurrence and progression of CKD is closely related to constitution of Qi deficiency,blood stasis and Yin deficiency.The above conclusions may be subject to the risk of bias due to factors such as the quantity and quality of the included primary literature,and thus requires further study.