巫山淫羊藿对甲状腺功能减退大鼠的影响

Effects of Wushan Epimedium on hypothyroid rats

目的研究巫山淫羊藿对甲状腺功能减退症的治疗作用。方法雄性大鼠分为正常组、模型组、巫山淫羊藿组三组,每组10只。模型组和巫山淫羊藿组用丙基硫氧嘧啶制备大鼠甲减模型,其中巫山淫羊藿组用巫山淫羊藿干预,模型组不干预。正常组给予生理盐水。在实验过程中,监测动物的整体状况,并记录饮水量。实验结束后,测定各组动物血清三碘甲状腺原氨酸(T_(3))、四碘甲状腺素(T_(4))、促甲状腺激素释放激素(TRH)、皮质醇(CORT)、17-羟皮质类固醇(17-OHCS)水平。结果模型组动物饮水量较正常组减少,差异具有统计学意义,血清检测指标显著降低;巫山淫羊藿组饮水量较模型组升高,差异具有统计学意义,一般状态有所改善,血清T_(3)、T_(4)、TRH、17-OHCS水平升高。结论基于本次实验,巫山淫羊藿对大鼠甲状腺功能减退症有一定的治疗作用。

Objective To study the therapeutic effect of Wushan Epimedium on hypothyroidism.Methods Male rats were divided into three groups:normal group,model group and Wushan Epimedium group,with 10 rats in each group.The model group and the Wushan Epimedium group were prepared with propylthioxypyrimethamine for the rat hypothyroidism model,in which the Wushan Epimedium group was intervened with Wushan Epimedium and the model group was not intervened.Saline was given to the normal group.During the experiment,the overall condition of the animals was monitored and the amount of water drunk was recorded.At the end of the experiment,serum triiodothyronine(T_(3)),tetraiodothyronine(T_(4)),thyrotropin-releasing hormone(TRH),cortisol(CORT),and 17-hydroxycorticosteroid(17-OHCS)levels were measured in the animals of each group.Results The animals in the model group drank less water than the normal group,and the difference was statistically significant,and the serum detection indexes were significantly reduced;the Wushan Epimedium group drank more water than the model group,and the difference was statistically significant,and the general condition was improved,and the serum T_(3),T_(4),TRH and 17-OHCS levels were increased.Conclusion Based on the present experiment,Wushan Epimedium had a therapeutic effect on hypothyroidism in rats.